Evidence map›Paper›PMID 39001381›Full record

ArticleCancers2024

Pro-Oxidant Auranofin and Glutathione-Depleting Combination Unveils Synergistic Lethality in Glioblastoma Cells with Aberrant Epidermal Growth Factor Receptor Expression.

Elvis Martinez-Jaramillo, Fatemeh Jamali, Farah H Abdalbari, Bassam Abdulkarim, Bertrand J Jean-Claude, Carlos M Telleria, Siham Sabri

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elvis Martinez-JaramilloExperimental Pathology Unit, McGill University, Montréal, QC H3A 2B4, Canada.ORCID 0000-0001-7726-4459
Fatemeh JamaliCancer Research Program, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.
Farah H AbdalbariExperimental Pathology Unit, McGill University, Montréal, QC H3A 2B4, Canada.
Bassam AbdulkarimCancer Research Program, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.
Bertrand J Jean-ClaudeDepartment of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montréal, QC H4A 3J1, Canada.
Carlos M TelleriaExperimental Pathology Unit, McGill University, Montréal, QC H3A 2B4, Canada.ORCID 0000-0003-1070-3538
Siham SabriCancer Research Program, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada.ORCID 0000-0001-5792-689X

Funding

Cancer Research Society 22716donation from the "Bawa Family Initiative" through McGill University Health Centre Foundation N/AOvCAN initiative of Ovarian Cancer Canada N/ASusan Aberman and Louis Dzialowski through The Montreal Neurological Hospital Foundation N/A
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most prevalent and advanced malignant primary brain tumor in adults. GBM frequently harbors epidermal growth factor receptor (EGFR) wild-type (

Indexed as

antioxidantauranofindrug repurposingEGFREGFRvIIIglioblastomaglutathione (GSH)oxidative stressreactive oxygen species (ROS)thioredoxin reductase (TrxR1)

Identifiers

PMID39001381
PMCPMC11240359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.