ReviewDiagnostics (Basel, Switzerland)2024
Is There a Relationship between Salivary Cortisol and Temporomandibular Disorder: A Systematic Review.
Review in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Biomarkers in Temporomandibular Disorders: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Evaluation of the salivary biomarker cortisol in patients with temporomandibular disorders.Journal of oral & facial pain and headache · 2026Observational
- Bruxism as a Biopsychosocial Disorder: An Interdisciplinary Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Bruxism and Stress: Ultrasonographic Masseter Muscle Assessment and Salivary Melatonin-Cortisol Dynamics.Journal of oral rehabilitation · 2025Article
- Blood glucose screening in dental clinics as an opportunity for detection of diabetes and prediabetes: The Kyoutou Dental and Diabetes (KDD) Study.Journal of diabetes investigation · 2025Article
- Stress and salivary cortisol levels among temporomandibular disorders: a case-control study.Journal of oral & facial pain and headache · 2025Article
- Distinguishing chronic pain from mechanical factors in chronic TMD: a narrative review.Journal of the Royal Society of New Zealand · 2025Review
- Neurofeedback Technology Reduces Cortisol Levels in Bruxismitle Patients: Assessment of Cerebral Activity and Anxiolytic Effects ofBiomimetics (Basel, Switzerland) · 2024Article
- Does salivary cortisol serve as a potential biomarker for temporomandibular disorders in adults?BMC oral health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis systematic review examines and evaluates the relationship between salivary cortisol levels and temporomandibular disorder (TMD) in young adult patients.
methodSix databases-PubMed, Scopus, Web of Science, Google Scholar, ProQuest, and Cochrane Library-were utilized to screen eligible studies. A systematic search was performed based on PECO questions and eligibility criteria. The research question for this review was "Do salivary cortisol levels correlate with TMD in individuals aged 18-40?" The risk of bias for quality assessment was determined by the Cochrane tool. PRISMA guidelines were followed while performing this review.
resultA total of fourteen studies were included in this review. Of these, eleven were observational studies (four cross-sectional and seven case-control), and three were randomized control trials. Eleven of the included studies presented a low to moderate risk in the qualitative synthesis. The total sample size of the included studies was 751 participants. The included studies suggest higher salivary cortisol levels in TMD patients than in healthy individuals.
conclusionsThe findings of this review indicate higher salivary cortisol levels in adult patients with TMD than in healthy controls. Thus, supportive psychological treatment and clinical modalities should be provided to patients with TMD. Moreover, higher-quality studies with low heterogeneity are required to support this finding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.