Evidence map›Paper›PMID 39001277›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Dynamic Perviousness Has Predictive Value for Clot Fibrin Content in Acute Ischemic Stroke.

Vania Anagnostakou, Daniel Toth, Gergely Bertalan, Susanne Müller, Regina R Reimann, Mark Epshtein, Jawid Madjidyar, Patrick Thurner, Tilman Schubert, Susanne Wegener and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Advances in Cerebrovascular Imaging and Interventions.Diagnostics (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vania AnagnostakouDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zürich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.ORCID 0000-0001-5101-3192
Daniel TothDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zürich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.
Gergely BertalanDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zürich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.ORCID 0009-0000-3986-9844
Susanne MüllerDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zürich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.
Regina R ReimannInstitute of Neuropathology, University Hospital Zürich, Schmelzbergstrasse 12, 8091 Zürich, Switzerland.ORCID 0000-0002-6396-4195
Mark EpshteinNew England Center for Stroke Research, Department of Radiology, University of Massachusetts Chan Medical School, 55 N Lake Ave, Worcester, MA 01655, USA.ORCID 0000-0002-1164-7331
Jawid MadjidyarDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zürich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.
Patrick ThurnerDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zürich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.
Tilman SchubertDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zürich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.
Susanne WegenerDepartment of Neurology, Clinical Neuroscience Center, University Hospital Zürich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.
Zsolt KulcsarDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zürich, Frauenklinikstrasse 10, 8091 Zürich, Switzerland.ORCID 0000-0002-6805-5150

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamic perviousness is a novel imaging biomarker, with clot density measurements at multiple timepoints to allow longer contrast to thrombus interaction. We investigated the correlations between dynamic perviousness and clot composition in the setting of acute ischemic stroke. Thirty-nine patients with large vessel occlusion (LVO) undergoing mechanical thrombectomy (MT) were analyzed. Patients received a three-phase CT imaging pre-thrombectomy and histopathological analysis of retrieved clots. Clot densities for every phase and change in densities between phases were calculated, leading to four patterns of dynamic perviousness: no contrast uptake, early contrast uptake with and without washout and late uptake. Clots were categorized into three groups based on dominant histologic composition: red blood cell (RBC)-rich, fibrin/platelet-rich and mixed. Clot composition was correlated with dynamic perviousness using the Kruskal-Wallis test and Pearson's correlation analysis. The dynamic perviousness categories showed a significant difference between fibrin-rich clots when compared to RBC-rich plus mixed groups. The uptake without washout category had significantly fewer fibrin clots compared to the uptake with washout (

Indexed as

blood clothistologypermeabilitystrokethrombectomy

Identifiers

PMID39001277
PMCPMC11241263

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.