Evidence map›Paper›PMID 39001232›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Acute Respiratory Tract Infections (ARTIs) in Children after COVID-19-Related Social Distancing: An Epidemiological Study in a Single Center of Southern Italy.

Raffaele Falsaperla, Vincenzo Sortino, Daria La Cognata, Chiara Barberi, Giovanni Corsello, Cristina Malaventura, Agnese Suppiej, Ausilia Desiree Collotta, Agata Polizzi, Patrizia Grassi and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07479394 (A Double-Blind, Randomized, Placebo-Controlled Trial of AHCC® Supplementation for Prevention of Respiratory Tract Infections Among Children Age 4-6 Years Old), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07479394 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Double-Blind, Randomized, Placebo-Controlled Trial of AHCC® Supplementation for Prevention of Respiratory Tract Infections Among Children Age 4-6 Years Old

TypeinterventionalSponsorHasanuddin UniversityRan2026 to 2027Enrolled60ConditionsRespiratory Tract Infections (RTI)Armsa prebiotic, that us a standardized extract of cultured Lentinula edodes mycelia, Placebo (dextrin)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Raffaele FalsaperlaNeonatal Intensive Care Unit and Neonatal Accompaniment Unit, San Marco Hospital, Azienda Ospedaliero-Universitaria Policlinico "Rodolico-San Marco", University of Catania, 95121 Catania, Italy.ORCID 0000-0002-4482-3506
Vincenzo SortinoUnit of Clinical Paediatrics, San Marco Hospital, Azienda Ospedaliero-Universitaria Policlinico, "Rodolico-San Marco", 95121 Catania, Italy.ORCID 0000-0002-0188-8430
Daria La CognataPostgraduate Training Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Chiara BarberiPostgraduate Training Program in Pediatrics, University of Palermo, 90121 Palermo, Italy.
Giovanni CorselloDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90121 Palermo, Italy.
Cristina MalaventuraMedical Sciences Department, University of Ferrara, 44124 Ferrara, Italy.
Agnese SuppiejMedical Sciences Department, University of Ferrara, 44124 Ferrara, Italy.
Ausilia Desiree CollottaUnit of Clinical Paediatrics, San Marco Hospital, Azienda Ospedaliero-Universitaria Policlinico, "Rodolico-San Marco", 95121 Catania, Italy.
Agata PolizziDepartment of Educational Science, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-4865-0200
Patrizia GrassiAnalysis Laboratory, San Marco Hospital, 95121 Catania, Italy.
Martino RuggieriUnit of Clinical Pediatrics, AOU "Policlinico", PO "G. Rodolico", University of Catania, 95123 Catania, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Sicily (Italy), respiratory syncytial virus (RSV), rhinovirus (HRV), and influenza virus triggered epidemics among children, resulting in an increase in acute respiratory tract infections (ARTIs). Our objective was to capture the epidemiology of respiratory infections in children, determining which pathogens were associated with respiratory infections following the lockdown and whether there were changes in the epidemiological landscape during the post-SARS-CoV-2 pandemic era. MATERIALS AND

methodsWe analyzed multiplex respiratory viral PCR data (BioFire

resultsViruses were predominantly responsible for ARTIs (99%), with RSV emerging as the most common agent involved in respiratory infections, followed by human rhinovirus/enterovirus and influenza A. RSV and rhinovirus were also the primary agents in coinfections. RSV predominated during winter months, while HRV/EV exhibited greater prevalence than RSV during the fall. Some viruses spread exclusively in coinfections (human coronavirus NL63, adenovirus, metapneumovirus, and parainfluenza viruses 1-3), while others primarily caused mono-infections (influenza A and B). SARS-CoV-2 was detected equally in both mono-infections (41%) and coinfections (59%).

conclusionsOur analysis underlines the predominance of RSV and the importance of implementing preventive strategies for RSV.

Indexed as

adenovirusBioFire® FilmArray® Respiratory Panel 2.1 PlusCOVID-19epidemiologyinfluenza Amultiplex PCRrespiratory infectionsrhinovirusRSVSARS-CoV-2

Identifiers

PMID39001232
PMCPMC11240751

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.