Evidence map›Paper›PMID 39000594›Full record

ArticleInternational journal of molecular sciences2024

Altered Inflammatory State and Mitochondrial Function Identified by Transcriptomics in Paediatric Congenital Heart Patients Prior to Surgical Repair.

Francesca Bartoli-Leonard, Amy G Harris, Kelly Saunders, Julie Madden, Carrie Cherrington, Karen Sheehan, Mai Baquedano, Giulia Parolari, Andrew Bamber, Massimo Caputo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francesca Bartoli-LeonardBristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1UD, UK.ORCID 0000-0001-7436-3873
Amy G HarrisBristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1UD, UK.ORCID 0000-0003-4749-6325
Kelly SaundersBristol Heart Institute, University Hospital Bristol and Weston NHS Foundation Trust, Bristol BS2 8ED, UK.
Julie MaddenBristol Heart Institute, University Hospital Bristol and Weston NHS Foundation Trust, Bristol BS2 8ED, UK.
Carrie CherringtonBristol Heart Institute, University Hospital Bristol and Weston NHS Foundation Trust, Bristol BS2 8ED, UK.
Karen SheehanBristol Heart Institute, University Hospital Bristol and Weston NHS Foundation Trust, Bristol BS2 8ED, UK.ORCID 0000-0003-1606-8184
Mai BaquedanoBristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1UD, UK.
Giulia ParolariBristol Heart Institute, University Hospital Bristol and Weston NHS Foundation Trust, Bristol BS2 8ED, UK.
Andrew BamberNorth Bristol NHS Trust, Westbury on Trym, Bristol BS10 5NB, UK.
Massimo CaputoBristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol BS8 1UD, UK.

Funding

British Heart Foundation CH/17/1/32804British Heart Foundation TA/F/21/210028Elizabeth Blackwell Institute for Health Research, University of Bristol ISSF3, 204813/Z/16/Z)Wellcome Trust
6 · The paper itself

Abstract

Congenital heart disease (CHD) remains the most common birth defect, with surgical intervention required in complex cases. Right ventricle (RV) function is known to be a major predictor of sustained cardiac health in these patients; thus, by elucidating the divergent profiles between CHD and the control through tissue analysis, this study aims to identify new avenues of investigation into the mechanisms surrounding reduced RV function. Transcriptomic profiling, in-silico deconvolution and functional network analysis were conducted on RV biopsies, identifying an increase in the mitochondrial dysfunction genes

Indexed as

Gene Expression ProfilingHeart Defects, CongenitalInflammationMitochondriaTranscriptomeChildChild, PreschoolFemaleGene Regulatory NetworksHumansInfantMalecongenital heart diseaseimmune cellright ventricleRNAseq

Identifiers

PMID39000594
PMCPMC11242307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.