Evidence map›Paper›PMID 39000564›Full record

ArticleInternational journal of molecular sciences2024

Unveiling New Genetic Variants Associated with Age at Onset in Alzheimer's Disease and Frontotemporal Lobar Degeneration Due to

Antonio Longobardi, Sonia Bellini, Roland Nicsanu, Andrea Pilotto, Andrea Geviti, Alessandro Facconi, Chiara Tolassi, Ilenia Libri, Claudia Saraceno, Silvia Fostinelli and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Antonio LongobardiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-8292-6434
Sonia BelliniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-6162-252X
Roland NicsanuMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-6621-8729
Andrea PilottoNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0003-2029-6606
Andrea GevitiService of Statistics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0003-0041-4142
Alessandro FacconiService of Statistics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0001-9060-6580
Chiara TolassiNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
Ilenia LibriNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-7334-5075
Claudia SaracenoMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0001-8618-4282
Silvia FostinelliMAC-Memory Clinic and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0003-0120-880X
Barbara BorroniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-9340-9814
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
Giuliano BinettiMAC-Memory Clinic and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-7691-1957

Funding

Italian Ministry of Health, Italy, Ricerca Finalizzata Grant RF-2019-12369272
6 · The paper itself

Abstract

Alzheimer's disease (AD) and Frontotemporal lobar degeneration (FTLD) represent the most common forms of neurodegenerative dementias with a highly phenotypic variability. Herein, we investigated the role of genetic variants related to the immune system and inflammation as genetic modulators in AD and related dementias. In patients with sporadic AD/FTLD (n = 300) and

Indexed as

Age of OnsetAlzheimer DiseaseC9orf72 ProteinFrontotemporal Lobar DegenerationAgedAged, 80 and overDNA Repeat ExpansionFemaleGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedPolymorphism, Single NucleotideTransferrinC9orf72 ProteinC9orf72 protein, humanTransferrinage at onsetAlzheimer’s diseaseC9orf72calsyntenin-1Frontotemporal lobar degenerationgenetic modulatorsGRNtransferrin

Identifiers

PMID39000564
PMCPMC11242823

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.