Evidence map›Paper›PMID 39000519›Full record

ArticleInternational journal of molecular sciences2024

CCR5 Δ32 and CTLA-4 +49 A/G Gene Polymorphisms and Interferon-β Treatment Response in Croatian and Slovenian Multiple Sclerosis Patients.

Jasna Nekić, Ivana Stanković Matić, Valentino Rački, Dolores Janko Labinac, Vladimira Vuletić, Miljenko Kapović, Smiljana Ristić, Borut Peterlin, Nada Starčević Čizmarević

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jasna NekićDepartment of Nuclear Medicine, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia.
Ivana Stanković MatićDepartment of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0009-0005-8630-8704
Valentino RačkiDepartment of Neurology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0000-0003-3246-0506
Dolores Janko LabinacDepartment of Neurology, General Hospital Center Pula, 52100 Pula, Croatia.
Vladimira VuletićDepartment of Neurology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
Miljenko KapovićDepartment of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
Smiljana RistićDepartment of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0000-0002-5484-6445
Borut PeterlinClinical Institute of Genomic Medicine, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0001-7824-4978
Nada Starčević ČizmarevićDepartment of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.

Funding

University of Rijeka uniri-biomed-18-137
6 · The paper itself

Abstract

The aim of the present study was to investigate the impact of CCR5 Δ32 and CTLA-4 polymorphisms on the response to IFN-β treatment in our cohort of MS patients from Croatia and Slovenia. Genomic DNA was obtained from 295 MS patients (230 female; 65 male) classified as responders (

Indexed as

CTLA-4 AntigenGene FrequencyInterferon-betaMultiple SclerosisPolymorphism, Single NucleotideReceptors, CCR5AdultCroatiaFemaleGenotypeHumansMaleMiddle AgedSloveniaTreatment OutcomeCCR5 protein, humanCTLA-4 AntigenCTLA4 protein, humanInterferon-betaReceptors, CCR5CCR5 Δ32CTLA-4 +49 A/GIFN-βmultiple sclerosispolymorphismtreatment response

Identifiers

PMID39000519
PMCPMC11242381

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.