Glutenin from the Ancient Wheat Progenitor Is Intrinsically Allergenic as It Can Clinically Sensitize Mice for Systemic Anaphylaxis by Activating Th2 Immune Pathway.

Rick Jorgensen, Tamil Selvan Arul Arasan, Maya Blanka Srkalovic, Chris Van Antwerp, Perry K W Ng, Venu Gangur

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Special Issue "Molecular Mechanisms and Treatment of Allergic Reactions".International journal of molecular sciences · 2025
Article
Advances in Mechanisms of Anaphylaxis in Wheat Allergy: Utility of Rodent Models.Foods (Basel, Switzerland) · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rick JorgensenFood Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USA.

Tamil Selvan Arul ArasanFood Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USA.

Maya Blanka SrkalovicFood Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USA.

Chris Van AntwerpFood Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USA.

Perry K W NgCereal Science Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USA.

Venu GangurFood Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USA.

Funding

The United States Department of Agriculture (USDA)/National Institute of Food and Agriculture (NIFA); Hatch project MICL02486 (Accession Number: 1012322), MICL02796, Hatch project MICL01699; Agricultural and Food Research Initiative Competitive Program, g 2018-67017-27876 (MICL05103)

6 · The paper itself

Abstract

Wheat allergy is a major type of food allergy with the potential for life-threatening anaphylactic reactions. Common wheat,

Indexed as

AllergensAnaphylaxisGlutensMice, Inbred BALB CTh2 CellsTriticumWheat HypersensitivityAnimalsDisease Models, AnimalFemaleImmunoglobulin EMast CellsMiceProteomicsAllergensgluteninGlutensImmunoglobulin Eancient wheatgluten allergygluteninlife-threatening anaphylaxissensitizationTh2 pathway

Identifiers

PMID39000431

DOI10.3390/ijms25137324

PMCPMC11242169

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.