Evidence map›Paper›PMID 39000430›Full record

ReviewInternational journal of molecular sciences2024

The Diagnostic Role of Skin Manifestations in Rheumatic Diseases in Children: A Critical Review of Paediatric Vasculitis.

Armando Di Ludovico, Marta Rinaldi, Federico Lauriola, Francesca Ciarelli, Saverio La Bella, Giulio Gualdi, Francesco Chiarelli, Kathryn Bailey, Luciana Breda

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Armando Di LudovicoPaediatric Department, University of Chieti "G. D'Annunzio", 66100 Chieti, Italy.ORCID 0000-0002-2644-1475
Marta RinaldiPaediatric Department, Buckinghamshire Healthcare NHS Trust, Aylesbury-Thames Valley Deanery, Oxford HP21 8AL, UK.
Federico LauriolaPaediatric Department, University of Chieti "G. D'Annunzio", 66100 Chieti, Italy.
Francesca CiarelliPaediatric Department, University of Chieti "G. D'Annunzio", 66100 Chieti, Italy.
Saverio La BellaPaediatric Department, University of Chieti "G. D'Annunzio", 66100 Chieti, Italy.ORCID 0000-0002-1244-0789
Giulio GualdiDermatology Clinic, Department of Medicine and Aging Science, University G D'Annunzio Chieti-Pescara, 66100 Chieti, Italy.
Francesco ChiarelliPaediatric Department, University of Chieti "G. D'Annunzio", 66100 Chieti, Italy.
Kathryn BaileyPaediatric Rheumatology, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK.
Luciana BredaPaediatric Department, University of Chieti "G. D'Annunzio", 66100 Chieti, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin lesions are frequently observed in children with rheumatic diseases, particularly in conditions such as IgA vasculitis (IgAV) and Kawasaki disease (KD). In paediatric vasculitis, the presence of skin lesions serves as an early indicator, emphasising the importance of timely diagnosis to prevent complications, such as cardiac or renal involvement. Conversely, autoinflammatory disorders like juvenile systemic lupus erythematosus (SLE) and juvenile dermatomyositis (DM) may manifest with cutaneous manifestations either at the onset of disease or during its progression. Identifying these skin lesions prior to the appearance of systemic symptoms offers an opportunity for early diagnosis and treatment, which has a positive influence on the outcomes. Additionally, it is noteworthy that specific rheumatological conditions, such as acute rheumatic fever (ARF) or oligoarticular or polyarticular forms of juvenile idiopathic arthritis (JIA), may exhibit occasional, but significant skin involvement, which is strongly correlated with an unfavourable prognosis. The assessment of skin is important in the holist approach to assessing patients for potentially systemic/multisystem disorder and helps distinguish discrete conditions.

Indexed as

Rheumatic DiseasesSkinVasculitisChildHumansMucocutaneous Lymph Node Syndromepaediatricskinvasculitis

Identifiers

PMID39000430
PMCPMC11242831

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.