A New Method for Growth Factor Enrichment from Dairy Products by Electrodialysis with Filtration Membranes: The Major Impact of Raw Product Pretreatment.

Sabita Kadel, Vladlen Nichka, Jacinthe Thibodeau, Behnaz Razi Parjikolaei, Laurent Bazinet

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Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Sabita KadelDairy Science and Technology Research Center (STELA), Institute of Nutrition and Functional Foods (INAF), Department of Food Sciences, Laval University, Quebec, QC G1V 0A6, Canada.

Vladlen NichkaDairy Science and Technology Research Center (STELA), Institute of Nutrition and Functional Foods (INAF), Department of Food Sciences, Laval University, Quebec, QC G1V 0A6, Canada.ORCID 0000-0002-6157-218X

Jacinthe ThibodeauDairy Science and Technology Research Center (STELA), Institute of Nutrition and Functional Foods (INAF), Department of Food Sciences, Laval University, Quebec, QC G1V 0A6, Canada.

Behnaz Razi ParjikolaeiArla Food Ingredients, Soenderupvej 26, DK-6920 Videbæk, Denmark.

Laurent BazinetDairy Science and Technology Research Center (STELA), Institute of Nutrition and Functional Foods (INAF), Department of Food Sciences, Laval University, Quebec, QC G1V 0A6, Canada.ORCID 0000-0002-6818-3558

Funding

Arla Foods Ingredients CI129730

6 · The paper itself

Abstract

This study is focused on fractionation of insulin-like growth factor I (IGF-I) and transforming growth factor-β2 (TGF-β2) using a new electro-based membrane process calledelectrodialysis with filtration membranes (EDFM). Before EDFM, different pretreatments were tested, and four pH conditions (4.25, 3.85, 3.45, and 3.05) were used during EDFM. It was demonstrated that a 1:1 dilution of defatted colostrum with deionized water to decrease mineral content followed by the preconcentration of GFs by UF is necessary and allow for these compounds to migrate to the recovery compartment during EDFM. MS analyses confirmed the migration, in low quantity, of only α-lactalbumin (α-la) and β-lactoglobulin (β-lg) from serocolostrum to the recovery compartment during EDFM. Consequently, the ratio of GFs to total protein in recovery compartment compared to that of feed serocolostrum solution was 60× higher at pH value 3.05, the optimal pH favoring the migration of IGF-I and TGF-β2. Finally, these optimal conditions were tested on acid whey to also demonstrate the feasibility of the proposed process on one of the main by-products of the cheese industry; the ratio of GFs to total protein was 2.7× higher in recovery compartment than in feed acid whey solution, and only α-la migrated. The technology of GF enrichment for different dairy solutions by combining ultrafiltration and electrodialysis technologies was proposed for the first time.

Indexed as

DialysisFiltrationAnimalsCattleColostrumDairy ProductsHydrogen-Ion ConcentrationInsulin-Like Growth Factor ILactalbuminLactoglobulinsMembranes, ArtificialWheyInsulin-Like Growth Factor ILactalbuminLactoglobulinsMembranes, Artificialcolostrumelectrodialysis with filtration membranesfiltration membranegrowth factorpretreatmentseparationwhey

Identifiers

PMID39000318

DOI10.3390/ijms25137211

PMCPMC11241186

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.