Evidence map›Paper›PMID 39000317›Full record

ArticleInternational journal of molecular sciences2024

Conjugate of Natural Bacteriochlorin with Doxorubicin for Combined Photodynamic and Chemotherapy.

Ekaterina Plotnikova, Olga Abramova, Petr Ostroverkhov, Aleksandra Vinokurova, Dmitry Medvedev, Sergei Tihonov, Maksim Usachev, Anastasia Shelyagina, Anastasija Efremenko, Alexey Feofanov and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ekaterina PlotnikovaNational Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.ORCID 0000-0001-8711-6919
Olga AbramovaNational Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.ORCID 0000-0003-3768-1439
Petr OstroverkhovDepartment of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119571 Moscow, Russia.ORCID 0000-0001-5778-4510
Aleksandra VinokurovaState Budgetary Educational Institution School, 1329 Moscow, Russia.
Dmitry MedvedevDepartment of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119571 Moscow, Russia.
Sergei TihonovDepartment of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119571 Moscow, Russia.ORCID 0000-0001-8262-3380
Maksim UsachevDepartment of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119571 Moscow, Russia.
Anastasia ShelyaginaDepartment of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119571 Moscow, Russia.
Anastasija EfremenkoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences, Miklukho-Maklaya str. 16/10, 117997 Moscow, Russia.ORCID 0000-0002-8263-3009
Alexey FeofanovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences, Miklukho-Maklaya str. 16/10, 117997 Moscow, Russia.ORCID 0000-0002-1596-9506
Andrey PankratovNational Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.ORCID 0000-0001-7291-9743
Petr ShegayNational Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
Mikhail GrinDepartment of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 119571 Moscow, Russia.
Andrey KaprinNational Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.

Funding

CSRD VA 1
6 · The paper itself

Abstract

Chemotherapy is among the main classical approaches to the treatment of oncologic diseases. Its efficiency has been comprehensively proven by clinical examinations; however, the low selectivity of chemotherapeutic agents limits the possibilities of this method, making it necessary to search for new approaches to the therapy of oncologic diseases. Photodynamic therapy is the least invasive method and a very efficient alternative for the treatment of malignant tumors; however, its efficiency depends on the depth of light penetration into the tissue and on the degree of oxygenation of the treatment zone. In this work, a hitherto unknown conjugate of a natural bacteriochlorin derivative and doxorubicin was obtained. In vitro and in vivo studies showed a more pronounced activity of the conjugate against MCF-7 and 4T1 cells and its higher tumorotropicity in animal tumor-bearing animals compared to free anthracycline antibiotic. The suggested conjugate implements the advantages of photodynamic therapy and chemotherapy and has great potential in cancer treatment.

Indexed as

DoxorubicinPhotochemotherapyPorphyrinsAnimalsAntibiotics, AntineoplasticAntineoplastic AgentsCell Line, TumorFemaleHumansMCF-7 CellsMiceMice, Inbred BALB CPhotosensitizing AgentsXenograft Model Antitumor AssaysAntibiotics, AntineoplasticAntineoplastic AgentsbacteriochlorinDoxorubicinPhotosensitizing AgentsPorphyrinschemotherapydoxorubicinnatural bacteriochlorinphotodynamic therapyphotosensitizerpolytherapy

Identifiers

PMID39000317
PMCPMC11241236

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.