Evidence map›Paper›PMID 39000316›Full record

ArticleInternational journal of molecular sciences2024

Production of Spinocerebellar Ataxia Type 3 Model Mice by Intravenous Injection of AAV-PHP.B Vectors.

Ayumu Konno, Yoichiro Shinohara, Hirokazu Hirai

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ayumu KonnoDepartment of Neurophysiology & Neural Repair, Gunma University Graduate School of Medicine, Maebashi 371-8511, Gunma, Japan.ORCID 0000-0001-9382-396X
Yoichiro ShinoharaDepartment of Neurophysiology & Neural Repair, Gunma University Graduate School of Medicine, Maebashi 371-8511, Gunma, Japan.
Hirokazu HiraiDepartment of Neurophysiology & Neural Repair, Gunma University Graduate School of Medicine, Maebashi 371-8511, Gunma, Japan.ORCID 0000-0002-0721-4293

Funding

Japan Agency for Medical Research and Development JP20dm0207057Japan Agency for Medical Research and Development JP21dm0207111Japan Society for the Promotion of Science 19K06899Japan Society for the Promotion of Science 22K06454Japan Society for the Promotion of Science 23H02791Japan Society for the Promotion of Science 24H01221
6 · The paper itself

Abstract

We aimed to produce a mouse model of spinocerebellar ataxia type 3 (SCA3) using the mouse blood-brain barrier (BBB)-penetrating adeno-associated virus (AAV)-PHP.B. Four-to-five-week-old C57BL/6 mice received injections of high-dose (2.0 × 10

Indexed as

Ataxin-3DependovirusDisease Models, AnimalGenetic VectorsMachado-Joseph DiseaseMice, Inbred C57BLAnimalsBlood-Brain BarrierInjections, IntravenousMicePromoter Regions, GeneticAtaxin-3AAVAAV-PHP.Badeno-associated virusMachado–Joseph diseasenuclear inclusion bodiesPurkinje cellSCA3Spinocerebellar ataxia type 3

Identifiers

PMID39000316
PMCPMC11241190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.