Evidence map›Paper›PMID 39000308›Full record

ArticleInternational journal of molecular sciences2024

Recapitulation of HIV-1 Neutralization Breadth in Plasma by the Combination of Two Broadly Neutralizing Antibodies from Different Lineages in the Same SHIV-Infected Rhesus Macaque.

Yanxin Gai, Nan Gao, Zhaoyang Mou, Chumeng Yang, Libian Wang, Wanshan Ji, Tiejun Gu, Bin Yu, Chu Wang, Xianghui Yu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yanxin GaiNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Nan GaoNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Zhaoyang MouNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Chumeng YangNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Libian WangNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Wanshan JiNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Tiejun GuNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Bin YuNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Chu WangNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.ORCID 0009-0009-9202-677X
Xianghui YuNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.ORCID 0000-0001-7739-1386
Feng GaoNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.

Funding

the "Medicine + X" Interdisciplinary Innovation Team of Norman Bethune Health Science Center of Jilin University 2022JBGS05the National Key Research and Development Program of China 2021YFC2301500the National Natural Science Foundation of China 31970888the National Natural Science Foundation of China 82002138the Research Fund for International Scientists of National Natural Science Fund of China 82350710801the Science and Technology Development Project of Jilin Province 20210402031GH
6 · The paper itself

Abstract

Viral infection generally induces polyclonal neutralizing antibody responses. However, how many lineages of antibody responses can fully represent the neutralization activities in sera has not been well studied. Using the newly designed stable HIV-1 Env trimer as hook, we isolated two distinct broadly neutralizing antibodies (bnAbs) from Chinese rhesus macaques infected with SHIV

Indexed as

Antibodies, NeutralizingHIV-1HIV AntibodiesMacaca mulattaSimian Acquired Immunodeficiency SyndromeAnimalsenv Gene Products, Human Immunodeficiency VirusHIV InfectionsHumansNeutralization TestsSimian Immunodeficiency VirusAntibodies, Neutralizingenv Gene Products, Human Immunodeficiency VirusHIV Antibodiesbroadly neutralizing antibodiesHIV-1neutralizationrhesus macaquesimian-human immunodeficiency virusvaccine

Identifiers

PMID39000308
PMCPMC11240982

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.