Evidence map›Paper›PMID 39000268›Full record

ArticleInternational journal of molecular sciences2024

In Vivo PET Detection of Lung Micrometastasis in Mice by Targeting Endothelial VCAM-1 Using a Dual-Contrast PET/MRI Probe.

Stavros Melemenidis, James C Knight, Veerle Kersemans, Francisco Perez-Balderas, Niloufar Zarghami, Manuel Sarmiento Soto, Bart Cornelissen, Ruth J Muschel, Nicola R Sibson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stavros MelemenidisDepartment of Radiation Oncology, Stanford School of Medicine, Cancer Institute, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3941-8784
James C KnightSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.ORCID 0000-0002-2952-5359
Veerle KersemansClinical Nuclear Medicine Imaging, Siemens Healthineers, 2595 BN The Hague, The Netherlands.
Francisco Perez-BalderasCureVac, AG. Paul-Ehrlich-Str. 15, 72076 Tubingen, Germany.
Niloufar ZarghamiDepartment of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Manuel Sarmiento SotoDepartment of Biochemistry and Molecular Biology, University of Seville, 41004 Seville, Spain.
Bart CornelissenDepartment of Nuclear Medicine, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Ruth J MuschelDepartment of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Nicola R SibsonDepartment of Oncology, University of Oxford, Oxford OX3 7DQ, UK.ORCID 0000-0003-1211-2766

Funding

Cancer Research UK C5255/A15935
6 · The paper itself

Abstract

Current clinical diagnostic imaging methods for lung metastases are sensitive only to large tumours (1-2 mm cross-sectional diameter), and early detection can dramatically improve treatment. We have previously demonstrated that an antibody-targeted MRI contrast agent based on microparticles of iron oxide (MPIO; 1 μm diameter) enables the imaging of endothelial vascular cell adhesion molecule-1 (VCAM-1). Using a mouse model of lung metastasis, upregulation of endothelial VCAM-1 expression was demonstrated in micrometastasis-associated vessels but not in normal lung tissue, and binding of VCAM-MPIO to these vessels was evident histologically. Owing to the lack of proton MRI signals in the lungs, we modified the VCAM-MPIO to include zirconium-89 (

Indexed as

Contrast MediaLung NeoplasmsMagnetic Resonance ImagingPositron-Emission TomographyVascular Cell Adhesion Molecule-1ZirconiumAnimalsCell Line, TumorFerric CompoundsHumansMiceNeoplasm MicrometastasisRadioisotopesContrast MediaFerric Compoundsferric oxideRadioisotopesVascular Cell Adhesion Molecule-1ZirconiumZirconium-89dual modality (PET/MRI)early detectionmicrometastasismicroparticles of iron oxide (MPIO)vascular cell adhesion molecule-1 (VCAM-1)

Identifiers

PMID39000268
PMCPMC11241628

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.