Evidence map›Paper›PMID 39000261›Full record

ArticleInternational journal of molecular sciences2024

Disulfidptosis: A Novel Prognostic Criterion and Potential Treatment Strategy for Diffuse Large B-Cell Lymphoma (DLBCL).

Yu Wang, Yoshiyuki Tsukamoto, Mitsuo Hori, Hidekatsu Iha

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yu WangDepartment of Microbiology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Yoshiyuki TsukamotoDepartment of Molecular Pathology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.ORCID 0000-0002-2827-8974
Mitsuo HoriDepartment of Hematology, Ibaraki Prefectural Central Hospital, Kasama 309-1703, Japan.
Hidekatsu IhaDepartment of Microbiology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.ORCID 0000-0002-0999-5636

Funding

Japan Society for the Promotion of Science 21K06925
6 · The paper itself

Abstract

Diffuse Large B-cell Lymphoma (DLBCL), with its intrinsic genetic and epigenetic heterogeneity, exhibits significantly variable clinical outcomes among patients treated with the current standard regimen. Disulfidptosis, a novel form of regulatory cell death triggered by disulfide stress, is characterized by the collapse of cytoskeleton proteins and F-actin due to intracellular accumulation of disulfides. We investigated the expression variations of disulfidptosis-related genes (DRGs) in DLBCL using two publicly available gene expression datasets. The initial analysis of DRGs in DLBCL (GSE12453) revealed differences in gene expression patterns between various normal B cells and DLBCL. Subsequent analysis (GSE31312) identified DRGs strongly associated with prognostic outcomes, revealing eight characteristic DRGs (

Indexed as

Gene Expression Regulation, NeoplasticLymphoma, Large B-Cell, DiffuseBiomarkers, TumorGene Expression ProfilingHumansPrognosisBiomarkers, Tumordiffuse large B-cell lymphoma (DLBCL)disulfidptosisdisulfidptosis-related genes (DRGs)immunitymachine learningprognosistreatment

Identifiers

PMID39000261
PMCPMC11241771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.