Evidence map›Paper›PMID 39000146›Full record

ArticleInternational journal of molecular sciences2024

Mutational Landscape of Alzheimer's Disease and Frontotemporal Dementia: Regional Variances in Northern, Central, and Southern Italy.

Claudia Saraceno, Lorenzo Pagano, Valentina Laganà, Andrea Geviti, Silvia Bagnoli, Assunta Ingannato, Salvatore Mazzeo, Antonio Longobardi, Silvia Fostinelli, Sonia Bellini and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Special Issue: The Role of Genetics in Dementia.International journal of molecular sciences · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Claudia SaracenoMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0001-8618-4282
Lorenzo PaganoMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0009-0007-0016-555X
Valentina LaganàDepartment of Primary Care, Regional Neurogenetic Centre (CRN), ASP Catanzaro, 88046 Lamezia Terme, Italy.ORCID 0000-0001-8379-400X
Andrea GevitiService of Statistics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0003-0041-4142
Silvia BagnoliDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50139 Florence, Italy.
Assunta IngannatoDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50139 Florence, Italy.ORCID 0000-0003-4955-0321
Salvatore MazzeoVita-Salute San Raffaele University, 20132 Milan, Italy.
Antonio LongobardiMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-8292-6434
Silvia FostinelliMAC-Memory Clinic and Molecular Markers, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0003-0120-880X
Sonia BelliniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-6162-252X
Alberto MontesantoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-9563-2216
Giuliano BinettiMAC-Memory Clinic and Molecular Markers, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Raffaele MalettaDepartment of Primary Care, Regional Neurogenetic Centre (CRN), ASP Catanzaro, 88046 Lamezia Terme, Italy.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50139 Florence, Italy.ORCID 0000-0001-9338-9040
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0002-7691-1957

Funding

Funded by the European Union - Next Generation EU - NRRP M6C2 - Investment 2.1 Enhance-ment and strengthening of biomedical research in the NHS PNRR-MR1-2022-12375654 - Cup Code: C83C22001300001. Title: Genetic and epigenetic modulAtors in Rare neurodegenerative diseases with DEmentia: a National study on autosomal dominant Alzheimer disease and genetic frontotemporal degeneration with dementIA (
6 · The paper itself

Abstract

Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD) are the two major neurodegenerative diseases with distinct clinical and neuropathological profiles. The aim of this report is to conduct a population-based investigation in well-characterized

Indexed as

Alzheimer DiseaseFrontotemporal DementiaMutationtau ProteinsAdultAgedAged, 80 and overAge of OnsetAmyloid beta-Protein PrecursorC9orf72 ProteinFemaleGenetic Predisposition to DiseaseHumansItalyMaleMiddle AgedAmyloid beta-Protein PrecursorC9orf72 ProteinC9orf72 protein, humanGRN protein, humanMAPT protein, humanPresenilin-1Presenilin-2ProgranulinsPSEN1 protein, humanPSEN2 protein, humantau ProteinsAlzheimer’s DiseaseAPPC9orf72Frontotemporal DementiageneGRNMAPTmutationPSEN1PSEN2

Identifiers

PMID39000146
PMCPMC11241147

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.