Evidence map›Paper›PMID 39000140›Full record

ArticleInternational journal of molecular sciences2024

The Expression of Toll-like Receptors (TLR7 and TLR9) in Class III and Class IV of Recently Diagnosed Lupus Nephritis with 12-Month Follow-Up.

José Ignacio Cerrillos-Gutiérrez, Miguel Medina-Pérez, Jorge Andrade-Sierra, Andrés García-Sánchez, Ernesto Germán Cardona-Muñoz, Wendy Campos-Pérez, Erika Martínez-López, Daniela Itzel Sánchez-Lozano, Tannia Isabel Campos-Bayardo, Daniel Román-Rojas and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

José Ignacio Cerrillos-GutiérrezDepartment of Nephrology, National Medical Center of the West, Mexican Social Security Institute, Guadalajara 44340, Jalisco, Mexico.
Miguel Medina-PérezDepartment of Nephrology, National Medical Center of the West, Mexican Social Security Institute, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-7259-4317
Jorge Andrade-SierraDepartment of Nephrology, National Medical Center of the West, Mexican Social Security Institute, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-1663-8223
Andrés García-SánchezDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara 44360, Jalisco, Mexico.ORCID 0000-0002-0924-4365
Ernesto Germán Cardona-MuñozDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara 44360, Jalisco, Mexico.ORCID 0000-0001-7868-667X
Wendy Campos-PérezDepartment of Molecular Biology and Genomics, Institute of Nutrigenetics and Translational Nutrigenomics, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-0483-7599
Erika Martínez-LópezDepartment of Molecular Biology and Genomics, Institute of Nutrigenetics and Translational Nutrigenomics, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-2005-9512
Daniela Itzel Sánchez-LozanoDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara 44360, Jalisco, Mexico.
Tannia Isabel Campos-BayardoDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara 44360, Jalisco, Mexico.
Daniel Román-RojasDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara 44360, Jalisco, Mexico.ORCID 0000-0002-4435-9686
Luis Francisco Gómez-HermosilloDepartment of Laparoscopic Surgery, Hospital Civil de Guadalajara, "Juan I Menchaca", Guadalajara 44360, Jalisco, Mexico.
Jorge Casillas-MorenoDepartment of Laparoscopic Surgery, Hospital Civil de Guadalajara, "Juan I Menchaca", Guadalajara 44360, Jalisco, Mexico.
Alejandra Guillermina Miranda-DíazDepartment of Physiology, University Center of Health Sciences, University of Guadalajara, Guadalajara 44360, Jalisco, Mexico.ORCID 0000-0002-3635-6135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal involvement is an important cause of morbidity and mortality in systemic lupus erythematosus (SLE). The present study included patients with recently diagnosed Class III and Class IV lupus nephritis (LN) treated by Rheumatology who, upon the detection of alterations in their kidney function, were referred to Nephrology for the joint management of both medical specialties. The purpose of this study was to compare the plasma expression of Toll-Like Receptor 7 (TLR7) and TLR9 in healthy control (HC) subjects and newly diagnosed Class III and Class IV LN patients with 12-month follow-ups. The plasma expression of TLR7 and TLR9 proteins was determined by the ELISA method. A significant increase in the expression of TLR7 protein was found in Class III LN in the basal determination compared to the expression in the HC (

Indexed as

Lupus NephritisToll-Like Receptor 7Toll-Like Receptor 9AdultCase-Control StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedYoung AdultTLR7 protein, humanTLR9 protein, humanToll-Like Receptor 7Toll-Like Receptor 9acquired immunityinnate immunitylupus nephritissystemic lupus erythematosusTLR7TLR9

Identifiers

PMID39000140
PMCPMC11241645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.