Evidence map›Paper›PMID 39000138›Full record

ArticleInternational journal of molecular sciences2024

Exploring the Efficacy of Peptides and Mimics against Influenza A Virus, Adenovirus, and Murine Norovirus.

Umme Laila Urmi, Ajay Kumar Vijay, Mark D P Willcox, Samuel Attard, George Enninful, Naresh Kumar, Salequl Islam, Rajesh Kuppusamy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Umme Laila UrmiSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0003-1327-1638
Ajay Kumar VijaySchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-8248-6379
Mark D P WillcoxSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0003-3842-7563
Samuel AttardSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
George EnninfulSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0003-0765-3867
Naresh KumarSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-0951-9621
Salequl IslamSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-6131-4132
Rajesh KuppusamySchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-9844-5064

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ongoing battle against viral pandemics continues, with the possibility of future outbreaks. The search for effective antiviral compounds that can combat a diverse range of viruses continues to be a focal point of research. This study investigated the efficacy of two natural antimicrobial peptides (AMPs) (lactoferricin and LL-37), two synthetic AMPs (melimine and Mel4), and nine AMP mimics (758, 1091, 1096, 1083, 610, NAPL, 3-BIPL, 4-BIPL, and Sau-22) against influenza A virus strains H1N1 and H3N2, human adenovirus 5 (HAdV-5), and murine norovirus 1 (MNV-1). These compounds were tested using virus pre-treatment, cell pre-treatment, or post-cell entry treatment assays, electron microscopy, and circular dichroism (CD), alongside evaluations of cytotoxicity against the host cells. After virus pre-treatment, the AMP mimics 610 and Sau-22 had relatively low IC

Indexed as

Antiviral AgentsNorovirusAdenoviridaeAnimalsAntimicrobial Cationic PeptidesAntimicrobial PeptidesDogsHumansInfluenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeMadin Darby Canine Kidney CellsMiceAntimicrobial Cationic PeptidesAntimicrobial PeptidesAntiviral Agentsadenovirusinfluenza A virusnoroviruspeptidepeptidomimetics

Identifiers

PMID39000138
PMCPMC11240954

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.