Evidence map›Paper›PMID 39000137›Full record

ArticleInternational journal of molecular sciences2024

Structure-Function Insights into the Dual Role in Nucleobase and Nicotinamide Metabolism and a Possible Use in Cancer Gene Therapy of the URH1p Riboside Hydrolase.

Alejandra Angela Carriles, Laura Muzzolini, Claudia Minici, Paola Tornaghi, Marco Patrone, Massimo Degano

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alejandra Angela CarrilesBiocrystallography Group, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy.ORCID 0000-0003-0481-2551
Laura MuzzoliniBiocrystallography Group, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy.
Claudia MiniciBiocrystallography Group, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy.ORCID 0000-0002-8350-484X
Paola TornaghiBiocrystallography Group, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy.
Marco PatroneBiocrystallography Group, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy.ORCID 0000-0002-5164-2877
Massimo DeganoBiocrystallography Group, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy.ORCID 0000-0002-0787-1883

Funding

Associazione Italiana per la Ricerca sul Cancro IG17032Associazione Italiana per la Ricerca sul Cancro IG25764
6 · The paper itself

Abstract

The URH1p enzyme from the yeast

Indexed as

NiacinamideSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsHumansModels, MolecularNeoplasmsN-Glycosyl HydrolasesPyridinium CompoundsStructure-Activity RelationshipSubstrate SpecificityUridineN-Glycosyl HydrolasesNiacinamidenicotinamide-beta-ribosidePyridinium CompoundsSaccharomyces cerevisiae ProteinsUridinecancer therapyenzymologymetabolismNAD+nucleosidesX-ray crystallography

Identifiers

PMID39000137
PMCPMC11241417

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.