Evidence map›Paper›PMID 39000131›Full record

ArticleInternational journal of molecular sciences2024

Designed De Novo α-Sheet Peptides Destabilize Bacterial Biofilms and Increase the Susceptibility of

Tatum Prosswimmer, Sarah E Nick, James D Bryers, Valerie Daggett

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. The Antimicrobial Peptide CRAMP-34 EradicatesAntibiotics (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tatum ProsswimmerMolecular Engineering Program, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-1228-347X
Sarah E NickDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-9683-7195
James D BryersDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-3332-3271
Valerie DaggettMolecular Engineering Program, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5116-6102

Funding

TRAINING IN MOLECULAR BIOPHYSICST32GM008268 · NIGMS · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M, ZHENG, NING · 1988 to 2023
$8.6M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Biomaterials that Promote Infection ImmunityR01AI074661 · NIAID · UNIVERSITY OF WASHINGTON · PI BRYERS, JAMES D. · 2008 to 2012
$2.5M
Injectable Hydrogel Depots for Self-replicating mRNA Vaccine DeliveryR01AI162840 · NIAID · UNIVERSITY OF WASHINGTON · PI BRYERS, JAMES D. · 2022 to 2025
$2.2M
NCATS NIH HHS TL1 TR002318NIAID NIH HHS R01 AI074661NIAID NIH HHS R01 AI162840NIGMS NIH HHS T32 GM008268NIGMS NIH HHS T32GM008268NIH HHS 6R01AI074661United States Department of Defense W81XWH-19-0050
6 · The paper itself

Abstract

Biofilm-associated microbes are 10-1000 times less susceptible to antibiotics. An emerging treatment strategy is to target the structural components of biofilm to weaken the extracellular matrix without introducing selective pressure. Biofilm-associated bacteria, including

Indexed as

Anti-Bacterial AgentsBiofilmsEscherichia coliMicrobial Sensitivity TestsStaphylococcus aureusAmyloidPeptidesAmyloidAnti-Bacterial AgentsPeptidesalpha-sheetamyloidantibiotic susceptibilitybiofilmEscherichia coliStaphylococcus aureus

Identifiers

PMID39000131
PMCPMC11241457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.