Evidence map›Paper›PMID 39000109›Full record

ArticleInternational journal of molecular sciences2024

PEGylated Micro/Nanoparticles Based on Biodegradable Poly(Ester Amides): Preparation and Study of the Core-Shell Structure by Synchrotron Radiation-Based FTIR Microspectroscopy and Electron Microscopy.

Davit Makharadze, Temur Kantaria, Ibraheem Yousef, Luis J Del Valle, Ramaz Katsarava, Jordi Puiggalí

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. From Nanoparticle Design to Clinical Translation in Cancer Therapy.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Davit MakharadzeDepartament de Enginyeria Química, Universitat Politècnica de Catalunya, EEBE, Av. Eduard Maristany 10-14, 08019 Barcelona, Spain.ORCID 0000-0003-0568-9399
Temur KantariaInstitute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Tbilisi 0159, Georgia.
Ibraheem YousefALBA Synchrotron Light Facility, Carrer de la Llum 2-26, Cerdanyola del Vallès, 08290 Barcelona, Spain.ORCID 0000-0001-7818-8611
Luis J Del ValleDepartament de Enginyeria Química, Universitat Politècnica de Catalunya, EEBE, Av. Eduard Maristany 10-14, 08019 Barcelona, Spain.ORCID 0000-0001-9916-1741
Ramaz KatsaravaInstitute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Tbilisi 0159, Georgia.ORCID 0000-0002-2373-1514
Jordi PuiggalíDepartament de Enginyeria Química, Universitat Politècnica de Catalunya, EEBE, Av. Eduard Maristany 10-14, 08019 Barcelona, Spain.ORCID 0000-0002-0640-4474

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surface modification of drug-loaded particles with polyethylene glycol (PEG) chains is a powerful tool that promotes better transport of therapeutic agents, provides stability, and avoids their detection by the immune system. In this study, we used a new approach to synthesize a biodegradable poly(ester amide) (PEA) and PEGylating surfactant. These were employed to fabricate micro/nanoparticles with a core-shell structure. Nanoparticle (NP)-protein interactions and self-assembling were subsequently studied by synchrotron radiation-based FTIR microspectroscopy (SR-FTIRM) and transmission electron microscopy (TEM) techniques. The core-shell structure was identified using IR absorption bands of characteristic chemical groups. Specifically, the stretching absorption band of the secondary amino group (3300 cm

Indexed as

NanoparticlesPolyestersPolyethylene GlycolsSynchrotronsAmidesMicroscopy, Electron, TransmissionSpectroscopy, Fourier Transform InfraredAmidesPolyestersPolyethylene Glycolselectron microscopymicrospectroscopynanoparticlespoly(ester amide)polyethylene glycolprotein adsorption

Identifiers

PMID39000109
PMCPMC11241343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.