Evidence map›Paper›PMID 39000105›Full record

ArticleInternational journal of molecular sciences2024

Cellular Therapy in Experimental Autoimmune Encephalomyelitis as an Adjuvant Treatment to Translate for Multiple Sclerosis.

Maiara Carolina Perussolo, Bassam Felipe Mogharbel, Cláudia Sayuri Saçaki, Nádia Nascimento da Rosa, Ana Carolina Irioda, Nathalia Barth de Oliveira, Julia Maurer Appel, Larissa Lührs, Leanderson Franco Meira, Luiz Cesar Guarita-Souza and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maiara Carolina PerussoloAdvanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Research Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, Curitiba P.O. Box 80240-020, Paraná, Brazil.ORCID 0000-0003-2617-7181
Bassam Felipe MogharbelAdvanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Research Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, Curitiba P.O. Box 80240-020, Paraná, Brazil.ORCID 0000-0002-1338-0693
Cláudia Sayuri SaçakiAdvanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Research Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, Curitiba P.O. Box 80240-020, Paraná, Brazil.
Nádia Nascimento da RosaAdvanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Research Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, Curitiba P.O. Box 80240-020, Paraná, Brazil.
Ana Carolina IriodaAdvanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Research Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, Curitiba P.O. Box 80240-020, Paraná, Brazil.
Nathalia Barth de OliveiraAdvanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Research Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, Curitiba P.O. Box 80240-020, Paraná, Brazil.ORCID 0000-0002-4034-2254
Julia Maurer AppelAdvanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Research Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, Curitiba P.O. Box 80240-020, Paraná, Brazil.
Larissa LührsAdvanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Research Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, Curitiba P.O. Box 80240-020, Paraná, Brazil.ORCID 0000-0001-6967-735X
Leanderson Franco MeiraExperimental Laboratory of the Institute of Biology and Health Sciences, Pontifical Catholic University of Paraná, Curitiba P.O. Box 80215-901, Paraná, Brazil.
Luiz Cesar Guarita-SouzaExperimental Laboratory of the Institute of Biology and Health Sciences, Pontifical Catholic University of Paraná, Curitiba P.O. Box 80215-901, Paraná, Brazil.ORCID 0000-0003-2781-9705
Seigo NagashimaLaboratory of Experimental Pathology, Graduate Program of Health Sciences, School of Medicine, Pontifical Catholic University of Paraná (PUCPR), Curitiba P.O. Box 80215-901, Paraná, Brazil.ORCID 0000-0003-0069-3823
Caroline Busatta Vaz de PaulaLaboratory of Experimental Pathology, Graduate Program of Health Sciences, School of Medicine, Pontifical Catholic University of Paraná (PUCPR), Curitiba P.O. Box 80215-901, Paraná, Brazil.ORCID 0000-0002-8434-8471
Lucia de NoronhaLaboratory of Experimental Pathology, Graduate Program of Health Sciences, School of Medicine, Pontifical Catholic University of Paraná (PUCPR), Curitiba P.O. Box 80215-901, Paraná, Brazil.ORCID 0000-0003-0310-7164
Idiberto José Zotarelli-FilhoPostgraduate Program in Food, Nutrition and Food Engineering, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (UNESP), São José do Rio Preto P.O. Box 15054-000, São Paulo, Brazil.
Eltyeb AbdelwahidFeinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Katherine Athayde Teixeira de CarvalhoAdvanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Research Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, Curitiba P.O. Box 80240-020, Paraná, Brazil.ORCID 0000-0003-4860-2855

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001
6 · The paper itself

Abstract

This study aims to evaluate and compare cellular therapy with human Wharton's jelly (WJ) mesenchymal stem cells (MSCs) and neural precursors (NPs) in experimental autoimmune encephalomyelitis (EAE), a preclinical model of Multiple Sclerosis. MSCs were isolated from WJ by an explant technique, differentiated to NPs, and characterized by cytometry and immunocytochemistry analysis after ethical approval. Forty-eight rats were EAE-induced by myelin basic protein and Freund's complete adjuvant. Forty-eight hours later, the animals received intraperitoneal injections of 250 ng/dose of Bordetella pertussis toxin. Fourteen days later, the animals were divided into the following groups: a. non-induced, induced: b. Sham, c. WJ-MSCs, d. NPs, and e. WJ-MSCs plus NPs. 1 × 10

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMultiple SclerosisAnimalsCell- and Tissue-Based TherapyDisease Models, AnimalFemaleHumansNeural Stem CellsRatsWharton Jellycellular therapyexperimental autoimmune encephalomyelitishumanimmunomodulatorymesenchymal stem cellsmultiple sclerosisneural precursorsneuroprotectiontranslationWharton’s jelly

Identifiers

PMID39000105
PMCPMC11241124

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.