Cysteine Oxidation in Human Galectin-1 Occurs Sequentially via a Folded Intermediate to a Fully Oxidized Unfolded Form.

Hans Ippel, Michelle C Miller, Ruud P M Dings, Anna-Kristin Ludwig, Hans-Joachim Gabius, Kevin H Mayo

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Hans IppelDepartment of Biochemistry, Molecular Biology & Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.ORCID 0000-0001-6589-6678

Michelle C MillerDepartment of Biochemistry, Molecular Biology & Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.

Ruud P M DingsDepartment of Biochemistry, Molecular Biology & Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.ORCID 0000-0001-7686-1331

Anna-Kristin LudwigDepartment of Veterinary Sciences, Physiological Chemistry, Ludwig-Maximilians-University, 80539 Munich, Germany.

Hans-Joachim GabiusDepartment of Veterinary Sciences, Physiological Chemistry, Ludwig-Maximilians-University, 80539 Munich, Germany.

Kevin H MayoDepartment of Biochemistry, Molecular Biology & Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Galectins are multifunctional effectors in cellular homeostasis and dysregulation. Oxidation of human galectin-1 (Gal-1) with its six sulfhydryls produces a disulfide-bridged oxidized form that lacks normal lectin activity yet gains new glycan-independent functionality. Nevertheless, the mechanistic details as to how Gal-1 oxidation occurs remain unclear. Here, we used

Indexed as

CysteineGalectin 1Oxidation-ReductionDisulfidesHumansLactoseModels, MolecularMutagenesis, Site-DirectedProtein FoldingProtein UnfoldingCysteineDisulfidesGalectin 1LactoseLGALS1 protein, humanagglutinationalarmindisulfide bridgesinflammationlectin

Identifiers

PMID39000066

DOI10.3390/ijms25136956

PMCPMC11241627

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.