Evidence map›Paper›PMID 38999964›Full record

ArticleInternational journal of molecular sciences2024

Hyaluron-Based Bionanocomposites of Silver Nanoparticles with Graphene Oxide as Effective Growth Inhibitors of Wound-Derived Bacteria.

Anna Lenart-Boroń, Klaudia Stankiewicz, Kinga Dworak, Klaudia Bulanda, Natalia Czernecka, Anna Ratajewicz, Karen Khachatryan, Gohar Khachatryan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna Lenart-BorońDepartment of Microbiology and Biomonitoring, Faculty of Agriculture and Economics, University of Agriculture in Kraków, Adam Mickiewicz Ave. 24/28, 30-059 Kraków, Poland.ORCID 0000-0003-3655-7567
Klaudia StankiewiczDepartment of Microbiology and Biomonitoring, Faculty of Agriculture and Economics, University of Agriculture in Kraków, Adam Mickiewicz Ave. 24/28, 30-059 Kraków, Poland.ORCID 0000-0001-6392-1454
Kinga DworakDiagnostyka S.A. Medical Microbiological Laboratory, Na Skarpie 66, 31-913 Kraków, Poland.
Klaudia BulandaDepartment of Forest Ecosystems Protection, Faculty of Forestry, University of Agriculture in Kraków, 29 Listopada Ave. 46, 31-425 Kraków, Poland.
Natalia CzerneckaScientific Circle of Biotechnologists, Faculty of Biotechnology and Horticulture, University of Agriculture in Kraków, 29 Listopada Ave. 54, 31-425 Kraków, Poland.
Anna RatajewiczScientific Circle of Biotechnologists, Faculty of Biotechnology and Horticulture, University of Agriculture in Kraków, 29 Listopada Ave. 54, 31-425 Kraków, Poland.
Karen KhachatryanLaboratory of Nanomaterials and Nanotechnology, Faculty of Food Technology, University of Agriculture in Kraków, Balicka Street 122, 30-149 Kraków, Poland.ORCID 0000-0001-7823-5406
Gohar KhachatryanDepartment of Food Quality Analysis and Assessment, Faculty of Food Technology, University of Agriculture in Kraków, Balicka Street 122, 30-149 Kraków, Poland.ORCID 0000-0002-4601-7145

Funding

Polish Ministry of Education and Science SKN/SP/569551/2023
6 · The paper itself

Abstract

Keeping wounds clean in small animals is a big challenge, which is why they often become infected, creating a risk of transmission to animal owners. Therefore, it is crucial to search for new biocompatible materials that have the potential to be used in smart wound dressings with both wound healing and bacteriostatic properties to prevent infection. In our previous work, we obtained innovative hyaluronate matrix-based bionanocomposites containing nanosilver and nanosilver/graphene oxide (Hyal/Ag and Hyal/Ag/GO). This study aimed to thoroughly examine the bacteriostatic properties of foils containing the previously developed bionanocomposites. The bacteriostatic activity was assessed in vitro on 88 Gram-positive (n = 51) and Gram-negative (n = 37) bacteria isolated from wounds of small animals and whose antimicrobial resistance patterns and resistance mechanisms were examined in an earlier study. Here, 69.32% of bacterial growth was inhibited by Hyal/Ag and 81.82% by Hyal/Ag/GO. The bionanocomposites appeared more effective against Gram-negative bacteria (growth inhibition of 75.68% and 89.19% by Hyal/Ag and Hyal/Ag/Go, respectively). The effectiveness of Hyal/Ag/GO against Gram-positive bacteria was also high (inhibition of 80.39% of strains), while Hyal/Ag inhibited the growth of 64.71% of Gram-positive bacteria. The effectiveness of Hyal/Ag and Hyal/Ag/Go varied depending on bacterial genus and species.

Indexed as

Anti-Bacterial AgentsGraphiteHyaluronic AcidMetal NanoparticlesMicrobial Sensitivity TestsNanocompositesSilverAnimalsBacteriaGram-Negative BacteriaGram-Positive BacteriaWound HealingAnti-Bacterial Agentsgraphene oxideGraphiteHyaluronic AcidSilverantibacterial activitygraphene oxidehyaluronic acidsilver nanoparticlestopical dressingswound infections

Identifiers

PMID38999964
PMCPMC11241533

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.