Evidence map›Paper›PMID 38999947›Full record

ReviewInternational journal of molecular sciences2024

Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models.

Aakriti Bhandari, Alexandra Seguin, Adrian Rothenfluh

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Frontiers in aging neuroscience · 2026
    Review
  3. Advances in drug addiction research usingFrontiers in cell and developmental biology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aakriti BhandariDepartment of Psychiatry, University of Utah, Salt Lake City, UT 84112, USA.
Alexandra SeguinMolecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA.
Adrian RothenfluhDepartment of Psychiatry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-3813-5723

Funding

Control of Alcohol Responses by Actin-Regulating GenesR01AA019526 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHENFLUH, ADRIAN · 2010 to 2025
$5.4M
Transcriptional Regulation of Alcohol Sensitivity and ToleranceR01AA030881 · NIAAA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Adrian Rothenfluh · 2023 to 2026
$2.1M
Mechanisms of alcohol-induced plasticitey mediated by Arf6R01AA026818 · NIAAA · UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2018 to 2022
$1.7M
The Genetics of Impulsivity and MotivationR21DA056241 · NIDA · UNIVERSITY OF UTAH · PI CHOW, CLEMENT, ROTHENFLUH, ADRIAN · 2023 to 2024
$424k
Alcohol Tolerance as a Driver of Self-AdministrationR21AA031795 · NIAAA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2024 to 2025
$405k
Genetics of Amphetamine PreferenceR21DA060453 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2024 to 2025
$383k
NIAAA NIH HHS R01 AA019526NIAAA NIH HHS R01 AA026818NIAAA NIH HHS R01AA026818, R01AA019536, R01AA030881NIAAA NIH HHS R01 AA030881NIAAA NIH HHS R21 AA031795NIDA NIH HHS R21 DA056241NIDA NIH HHS R21DA056241NIDA NIH HHS R21 DA060453
6 · The paper itself

Abstract

Alcohol tolerance is a neuroadaptive response that leads to a reduction in the effects of alcohol caused by previous exposure. Tolerance plays a critical role in the development of alcohol use disorder (AUD) because it leads to the escalation of drinking and dependence. Understanding the molecular mechanisms underlying alcohol tolerance is therefore important for the development of effective therapeutics and for understanding addiction in general. This review explores the molecular basis of alcohol tolerance in invertebrate models,

Indexed as

Caenorhabditis elegansEthanolNeuronal PlasticitySynaptic TransmissionAlcoholismAnimalsDrosophilaDrug ToleranceHumansInvertebratesSynapsesEthanolalcohol toleranceAUDC. elegansDrosophilainvertebratesneuroplasticityneurotransmission

Identifiers

PMID38999947
PMCPMC11241699

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.