SynthesisInternational journal of molecular sciences2024
The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseases-A Systematic Review.
Synthesis in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The role of exercise in MFN2 regulation in osteoarthritis.Molecular biology reports · 2026Review
- Physical exercise and miR-146a in type 2 diabetes and obesity: a narrative review.Molecular biology reports · 2026Review
- Sepsis Dysregulates Mitochondrial microRNA and Biogenesis in the Diaphragm but Not Limb Muscle.International journal of molecular sciences · 2026Article
- Skeletal muscle dysfunction in COPD: miRNAs, myokines and exercise.ERJ open research · 2026Review
- Metabolic Overdrive in Elite Sport: A Systems Model of AMPK-mTOR Oscillation, NADInternational journal of molecular sciences · 2026Review
- A circulating microRNA-based diagnostic model for breast cancer, in which the miR-139-3p/RPA2 axis regulates the sensitivity to DNA-damaging agents.Translational cancer research · 2026Article
- MicroRNA Regulatory Targets Related to VObioRxiv : the preprint server for biology · 2026Article
- Training Load Oscillation and Epigenetic Plasticity: Molecular Pathways Connecting Energy Metabolism and Athletic Personality.International journal of molecular sciences · 2026Review
- Lifelong football training influences miR-1303 serum expression and human breast cancer MCF-7 cells motility: a pilot study.Frontiers in sports and active living · 2026Article
- A scoping review of 24-h movement behaviours research in Chinese children and adolescents.Frontiers in public health · 2026Article
- Sociodemographic determinants of the level of physical activity in residents of Eastern Poland.BMC public health · 2025Article
- Exercise-Induced Biomarker Modulation in Sarcopenia: From Inflamm-Aging to Muscle Regeneration.Sports (Basel, Switzerland) · 2025Review
- MicroRNA signatures of cardiorespiratory fitness (VO2peak) in older adults: Insights from the study of muscle, mobility, and aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Utilizing Circulating MicroRNAs for Personalized Exercise Programs: Insights into Physiological Adaptations and Individual Responses.Iranian journal of biotechnology · 2025Review
- Review
- Exercise training partly ameliorates cardiac dysfunction in mice during doxorubicin treatment of breast cancer.Journal of translational medicine · 2025Article
- Article
- The impacts of natural polyphenols and exercise alone or together on microRNAs and angiogenic signaling.Frontiers in pharmacology · 2025Review
- Maximal and sub-maximal exercise tests alter PBMC microRNA expression: insights into sport- and sex-specific variations.Frontiers in physiology · 2025Article
- Regulating the expression of exercise-induced micro-RNAs and long non-coding RNAs: implications for controlling cardiovascular diseases and heart failure.Frontiers in molecular biosciences · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise may differently affect the expression of key molecular markers, including skeletal muscle and circulating miRNAs, involved in cellular and metabolic pathways' regulation in healthy individuals and in patients suffering from non-communicable diseases (NCDs). Epigenetic factors are emerging as potential therapeutic biomarkers in the prognosis and treatment of NCDs and important epigenetic factors, miRNAs, play a crucial role in cellular pathways. This systematic review aims to underline the potential link between changes in miRNA expression after different types of physical activity/exercise in some populations affected by NCDs. In June 2023, we systematically investigated the following databases: PubMed, MEDLINE, Scopus, and Web of Science, on the basis of our previously established research questions and following the PRISMA guidelines. The risk of bias and quality assessment were, respectively, covered by ROB2 and the Newcastle Ottawa scale. Of the 1047 records extracted from the initial search, only 29 studies were found to be eligible. In these studies, the authors discuss the association between exercise-modulated miRNAs and NCDs. The NCDs included in the review are cancer, cardiovascular diseases (CVDs), chronic obstructive pulmonary disease (COPD), and type 2 diabetes mellitus (T2DM). We evidenced that miR-146, miR-181, miR-133, miR-21, and miRNA-1 are the most reported miRNAs that are modulated by exercise. Their expression is associated with an improvement in health markers and they may be a potential target in terms of the development of future therapeutic tools.
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