ArticleNutrients2024
Blood Lead Mediates the Relationship between Biological Aging and Hypertension: Based on the NHANES Database.
Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship between lead exposure and different types of hypertension: systematic review and dose-response meta-analysis.Frontiers in public health · 2025Pooled it
- Effects of Micronutrients and Heavy Metals on Endothelial Function and Cardiovascular Risk in the Face of Environmental Changes.Current issues in molecular biology · 2025Review
- The association between whole-blood lead concentration and all-cause or cardiovascular disease mortality in hypertensive patients.Scientific reports · 2025Article
- The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses.Cardiovascular diabetology · 2025Article
- Integrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics.European journal of medical research · 2025Article
- The association between novel metabolic parameters and all-cause/cardiovascular mortality in patients with metabolic syndrome is modified by age.Cardiovascular diabetology · 2025Article
- Associations between heavy metal exposure and vascular age: a large cross-sectional study.Journal of translational medicine · 2025Article
- Association between novel adiposity parameters and hyperuricemia: a cross-sectional study.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Hypertension remains a major global public health crisis due to various contributing factors, such as age and environmental exposures. This study delves into exploring the intricate association between biological aging, blood lead levels, and hypertension, along with examining the mediating role of blood lead levels in the relationship between biological aging and hypertension. We analyzed data from two cycles of the NHANES, encompassing 4473 individuals aged 18 years and older. Our findings indicate that biological aging potentially escalates the risk of hypertension and the incidences of systolic blood pressure (SBP) and diastolic blood pressure (DBP) abnormalities. Utilizing weighted quantile sum (WQS) and quantile g-computation (QGC) model analyses, we observed that exposure to heavy metal mixtures, particularly lead, may elevate the likelihood of hypertension, SBP, and DBP abnormalities. Further mediation analysis revealed that lead significantly mediated the relationship between biological aging and hypertension and between biological aging and SBP abnormalities, accounting for 64% (95% CI, 49% to 89%) and 64% (95% CI, 44% to 88%) of the effects, respectively. These outcomes emphasize the criticality of implementing environmental health measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.