Evidence map›Paper›PMID 38999225›Full record

ReviewJournal of clinical medicine2024

Exploring Headaches in Pediatric Behçet Disease: Prevalence, Clinical Impact, and Management.

Andrea Santangelo, Antonio Corsello, Gilda Gizzi, Maddalena Lancieri, Maria Cristina Diana, Federica Trucco, Alessandro Orsini, Alice Bonuccelli, Diego Giampietro Peroni, Lorenzo Perilli and 4 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. [Clinical characteristics of Behçet syndrome in 45 children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andrea SantangeloDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16100 Genoa, Italy.ORCID 0000-0003-2668-6373
Antonio CorselloDepartment of Clinical Science and Community Health, University of Milan, 20122 Milan, Italy.ORCID 0000-0003-4578-0066
Gilda GizziPediatric Neurology and Muscular Diseases Unit, Pediatric Department, IRCCS Istituto G. Gaslini, 16100 Genoa, Italy.
Maddalena LancieriPediatric Neurology and Muscular Diseases Unit, Pediatric Department, IRCCS Istituto G. Gaslini, 16100 Genoa, Italy.
Maria Cristina DianaPediatric Neurology and Muscular Diseases Unit, Pediatric Department, IRCCS Istituto G. Gaslini, 16100 Genoa, Italy.ORCID 0000-0002-3594-068X
Federica TruccoPediatric Neurology and Muscular Diseases Unit, Pediatric Department, IRCCS Istituto G. Gaslini, 16100 Genoa, Italy.ORCID 0000-0002-1147-0126
Alessandro OrsiniPediatric Neurology, Pediatric Department, AOUP Santa Chiara Hospital, 56126 Pisa, Italy.ORCID 0000-0001-5256-6573
Alice BonuccelliPediatric Neurology, Pediatric Department, AOUP Santa Chiara Hospital, 56126 Pisa, Italy.ORCID 0000-0002-7457-2779
Diego Giampietro PeroniPediatric Neurology, Pediatric Department, AOUP Santa Chiara Hospital, 56126 Pisa, Italy.ORCID 0000-0002-0234-1373
Lorenzo PerilliClinical Paediatrics, Department of Molecular Medicine and Development, University of Siena, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy.ORCID 0000-0002-8630-6718
Edvige CorrentiChild Neurology and Psychiatry Unit-ISMEP, "G. Di Cristina" Children's Hospital-ARNAS Civico, 90127 Palermo, Italy.
Giuseppe SantangeloChild Neurology and Psychiatry Unit-ISMEP, "G. Di Cristina" Children's Hospital-ARNAS Civico, 90127 Palermo, Italy.
Pasquale StrianoDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16100 Genoa, Italy.ORCID 0000-0002-6065-1476
Vincenzo RaieliChild Neurology and Psychiatry Unit-ISMEP, "G. Di Cristina" Children's Hospital-ARNAS Civico, 90127 Palermo, Italy.ORCID 0000-0001-6149-0881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Behçet's Disease (BD), also recognized as Behçet Syndrome, manifests uniquely in pediatric populations as Pediatric Behçet's Disease (PBD), characterized by multisystemic inflammatory symptoms including recurrent oral and genital aphthae, and diverse ocular, vascular, and neurological involvements. This review elucidates the prevalence, burden, and management strategies of headaches in children with PBD, focusing on both primary headaches, such as migraine and tension-type headaches, and secondary headaches linked to systemic disease manifestations. It explores the pathophysiological underpinnings specific to PBD-related headaches and discusses the intricate relationship between systemic inflammatory processes and neurological symptoms. By examining the literature from 2004 to 2024, this study highlights the high frequency of headache in PBD patients, underscoring its diagnostic and clinical significance. We aim to provide a detailed understanding of headache management in PBD, emphasizing tailored therapeutic strategies that address the unique challenges faced by this patient population. This review also underscores the importance of comprehensive clinical evaluations to optimize outcomes and mitigate long-term sequelae, proposing that awareness and understanding of headache in PBD can significantly enhance both diagnosis and management.

Indexed as

Behçet’s diseaseheadachemigraineneuro-Behcetpediatric Behçet syndromevasculitis

Identifiers

PMID38999225
PMCPMC11242365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.