Evidence map›Paper›PMID 38999160›Full record

ArticleMolecules (Basel, Switzerland)2024

Film Coating of Phosphorylated Mandua Starch on Matrix Tablets for pH-Sensitive Release of Mesalamine.

Mayank Kumar Malik, Vipin Kumar, Vinoth Kumarasamy, Om Prakash Singh, Mukesh Kumar, Raghav Dixit, Vetriselvan Subramaniyan, Jaspal Singh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mayank Kumar MalikDepartment of Chemistry, Gurukula Kangri (Deemed to be University), Haridwar 249407, India.
Vipin KumarDepartment of Pharmaceutical Sciences, Gurukula Kangri (Deemed to be University), Haridwar 249407, India.
Vinoth KumarasamyDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-8895-1796
Om Prakash SinghDepartment of Kaya Chikitsa, Rishikul Campus, Haridwar, Uttarakhand Ayurved University, Dehradun 248001, India.
Mukesh KumarDepartment of Botany and Microbiology, Gurukula Kangri (Deemed to be University), Haridwar 249407, India.
Raghav DixitDepartment of Pharmaceutical Sciences, Gurukula Kangri (Deemed to be University), Haridwar 249407, India.ORCID 0000-0002-5494-191X
Vetriselvan SubramaniyanPharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 47500, Malaysia.ORCID 0000-0002-9629-9494
Jaspal SinghDepartment of Chemistry, Gurukula Kangri (Deemed to be University), Haridwar 249407, India.ORCID 0000-0003-1063-4931

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemically modified mandua starch was successfully synthesized and applied to coat mesalamine-loaded matrix tablets. The coating material was an aqueous dispersion of mandua starch modified by sodium trimetaphosphate and sodium tripolyphosphate. To investigate the colon-targeting release competence, chemically modified mandua starch film-coated mesalamine tablets were produced using the wet granulation method followed by dip coating. The effect of the coating on the colon-targeted release of the resultant delivery system was inspected in healthy human volunteers and rabbits using roentgenography. The results show that drug release was controlled when the coating level was 10%

Indexed as

Drug LiberationMesalamineStarchTabletsAnimalsColonDelayed-Action PreparationsHumansHydrogen-Ion ConcentrationPhosphorylationRabbitsDelayed-Action PreparationsMesalamineStarchTabletsdip coatingpH sensitive releaseresistant starch

Identifiers

PMID38999160
PMCPMC11243319

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.