ArticleMolecules (Basel, Switzerland)2024
A Comprehensive Analysis of Fel Ursi and Its Common Adulterants Based on UHPLC-QTOF-MS
Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Comprehensive Analysis of Bile-derived Medicinal Materials Based on Ultra-High-Performance Liquid Chromatography Coupled With Charged Aerosol Detection and Chemometrics.Analytical science advances · 2025Article
- Identification of bile powder based on component data matrix and progressive matching strategy combined with UHPLC-QTOF-MS.Biochemistry and biophysics reports · 2025Article
- Analysis of Saposhnikoviae Radix and Libonotidis Radix Based on "Characteristic Ion Set" and Chemometrics.Journal of mass spectrometry : JMS · 2025Article
- Traceability and Adulteration Analysis of Citri Reticulatae Pericarpium Based on "Digital Identity Card" and UHPLC-QTOF-MS Analysis.Food science & nutrition · 2025Article
- Comprehensive Analysis of Bile Medicines Based on UHPLC-QTOF-MSACS omega · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundAs one of the four most valuable animal medicines, Fel Ursi, named Xiong Dan (XD) in China, has the effect of clearing heat, calming the liver, and brightening the eyes. However, due to the special source of XD and its high price, other animals' bile is often sold as XD or mixed with XD on the market, seriously affecting its clinical efficacy and consumers' rights and interests. In order to realize identification and adulteration analysis of XD, UHPLC-QTOF-MS
methodsXD, pig gall (Zhu Dan, ZD), cow gall (Niu Dan, ND), rabbit gallbladder (Tu Dan, TD), duck gall (Yan Dan, YD), sheep gall (Yang Dan, YND), and chicken gall (Ji Dan, JD) were analyzed by UHPLC-QTOF-MS
resultsThe results showed that XD and six other animals' bile can be distinguished from each other obviously, with 27 ions with VIP > 1.0. We preliminarily identified 10 different bile acid-like components in XD and the other animals' bile with significant differences (
conclusionsThe developed method was efficient and rapid in accurately distinguishing between XD and six other animals' bile. Based on the obtained chemical composition markers, it is beneficial to strengthen quality control for bile medicines.
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