Evidence map›Paper›PMID 38999077›Full record

ArticleMolecules (Basel, Switzerland)2024

Identification of 3-((4-Hydroxyphenyl)amino)propanoic Acid Derivatives as Anticancer Candidates with Promising Antioxidant Properties.

Povilas Kavaliauskas, Birutė Grybaitė, Birute Sapijanskaite-Banevič, Kazimieras Anusevičius, Ilona Jonuškienė, Rima Stankevičienė, Rūta Petraitienė, Vidmantas Petraitis, Ramunė Grigalevičiūtė, Edita Meškinytė and 2 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Povilas KavaliauskasDepartment of Organic Chemistry, Kaunas University of Technology, LT-50254 Kaunas, Lithuania.ORCID 0000-0003-0237-9088
Birutė GrybaitėDepartment of Organic Chemistry, Kaunas University of Technology, LT-50254 Kaunas, Lithuania.ORCID 0000-0003-0982-1342
Birute Sapijanskaite-BanevičDepartment of Organic Chemistry, Kaunas University of Technology, LT-50254 Kaunas, Lithuania.
Kazimieras AnusevičiusDepartment of Organic Chemistry, Kaunas University of Technology, LT-50254 Kaunas, Lithuania.ORCID 0000-0003-4505-4611
Ilona JonuškienėDepartment of Organic Chemistry, Kaunas University of Technology, LT-50254 Kaunas, Lithuania.ORCID 0000-0002-6865-6888
Rima StankevičienėDepartment of Organic Chemistry, Kaunas University of Technology, LT-50254 Kaunas, Lithuania.
Rūta PetraitienėDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, NY 10065, USA.ORCID 0000-0002-3269-8058
Vidmantas PetraitisDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, NY 10065, USA.ORCID 0000-0001-6811-4467
Ramunė GrigalevičiūtėBiological Research Center, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.
Edita MeškinytėCenter of Animal Production Research and Innovation, Agriculture Academy, Vytautas Magnus University, LT-44248 Kaunas, Lithuania.
Rolandas StankevičiusDepartment of Animal Nutrition, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.ORCID 0000-0002-8036-9662
Vytautas MickevičiusDepartment of Organic Chemistry, Kaunas University of Technology, LT-50254 Kaunas, Lithuania.ORCID 0000-0002-9961-2941

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various cancer-associated morbidities remain a growing global health challenge, resulting in a significant burden on healthcare systems worldwide due to high mortality rates and a frequent lack of novel therapeutic options for advanced and localized disease. Reactive oxygen species (ROS) play an important role in cancer pathogenesis and response to chemotherapeutics; therefore, it is crucial to develop novel compounds with both antioxidant and anticancer activity. In this study, a series of previously reported 3-((4-hydroxyphenyl)amino)propanoic acid derivatives (compounds

Indexed as

Antineoplastic AgentsAntioxidantsCell SurvivalA549 CellsAnimalsCell MovementCell ProliferationChlorocebus aethiopsHumansMolecular StructurePropionatesReactive Oxygen SpeciesStructure-Activity RelationshipVero CellsAntineoplastic AgentsAntioxidantsPropionatesReactive Oxygen Species3-((4-hydroxyphenyl)amino)propanoic acid derivativesA549anticancer

Identifiers

PMID38999077
PMCPMC11243380

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.