A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist.

Solomon A Gisemba, Michael J Ferracane, Thomas F Murray, Jane V Aldrich

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Energy-Resolved Mass Spectrometry and Mid-Infrared Spectroscopy for Purity Assessment of a Synthetic Peptide Cyclised by Intramolecular Huisgen Click Chemistry.Methods and protocols · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Solomon A GisembaDepartment of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, USA.

Michael J FerracaneDepartment of Chemistry, University of Redlands, Redlands, CA 92373, USA.

Thomas F MurrayDepartment of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68102, USA.ORCID 0000-0001-8521-4507

Jane V AldrichDepartment of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-7954-9850

Funding

Peptidic Ligands for Kappa Opioid ReceptorsR01DA018832 · NIDA · UNIVERSITY OF KANSAS LAWRENCE · PI ALDRICH, JANE V · 2005 to 2016

$3.1M

NIDA NIH HHS R01 DA018832NIH HHS R01 DA018832

6 · The paper itself

Abstract

Kappa opioid receptor (KOR) antagonists have potential therapeutic applications in the treatment of stress-induced relapse to substance abuse and mood disorders. The dynorphin A analog arodyn (Ac[Phe

Indexed as

DynorphinsReceptors, Opioid, kappaAmino Acid SequenceAnimalsHumansModels, MolecularPeptides, CyclicStructure-Activity RelationshiparodynDynorphinsPeptides, CyclicReceptors, Opioid, kappabicyclic peptidecyclic peptidedynorphin analogkappa opioid receptor (KOR) antagonistring-closing metathesis (RCM)tyrosine(O-allyl)

Identifiers

PMID38999061

DOI10.3390/molecules29133109

PMCPMC11243530

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.