Evidence map›Paper›PMID 38999055›Full record

ArticleMolecules (Basel, Switzerland)2024

Solid Lipid Nanoparticles Encapsulating a Benzoxanthene Derivative in a Model of the Human Blood-Brain Barrier: Modulation of Angiogenic Parameters and Inflammation in Vascular Endothelial Growth Factor-Stimulated Angiogenesis.

Giuliana Greco, Aleksandra Agafonova, Alessia Cosentino, Nunzio Cardullo, Vera Muccilli, Carmelo Puglia, Carmelina Daniela Anfuso, Maria Grazia Sarpietro, Gabriella Lupo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giuliana GrecoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0009-0005-1216-1594
Aleksandra AgafonovaDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-8253-0598
Alessia CosentinoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.
Nunzio CardulloDepartment of Chemical Sciences, University of Catania, 95125 Catania, Italy.ORCID 0000-0003-1480-0861
Vera MuccilliDepartment of Chemical Sciences, University of Catania, 95125 Catania, Italy.ORCID 0000-0002-6212-5154
Carmelo PugliaDepartment of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.ORCID 0000-0002-7694-3641
Carmelina Daniela AnfusoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-7951-1812
Maria Grazia SarpietroDepartment of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.ORCID 0000-0002-6799-4754
Gabriella LupoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-9291-6969

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lignans, a class of secondary metabolites found in plants, along with their derivatives, exhibit diverse pharmacological activities, including antioxidant, antimicrobial, anti-inflammatory, and antiangiogenic ones. Angiogenesis, the formation of new blood vessels from pre-existing ones, is a crucial process for cancer growth and development. Several studies have elucidated the synergistic relationship between angiogenesis and inflammation in various inflammatory diseases, highlighting a correlation between inflammation and vascular endothelial growth factor (VEGF)-induced angiogenesis. Thus, the identification of novel molecules capable of modulating VEGF effects presents promising prospects for developing therapies aimed at stabilizing, reversing, or even arresting disease progression. Lignans often suffer from low aqueous solubility and, for their use, encapsulation in a delivery system is needed. In this research, a bioinspired benzoxantene has been encapsulated in solid lipid nanoparticles that have been characterized for their pharmacotechnical properties and their thermotropic behavior. The effects of these encapsulated nanoparticles on angiogenic parameters and inflammation in VEGF-induced angiogenesis were evaluated using human brain microvascular endothelial cells (HBMECs) as a human blood-brain barrier model.

Indexed as

Blood-Brain BarrierInflammationNanoparticlesVascular Endothelial Growth Factor AAngiogenesisEndothelial CellsHumansLipidsLiposomesNeovascularization, PathologicNeovascularization, PhysiologicLipid NanoparticlesLipidsLiposomesVascular Endothelial Growth Factor Abenzo[k,l]xanthene lignansblood–brain barrierSLNsVEGF-induced angiogenesis

Identifiers

PMID38999055
PMCPMC11243179

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.