Colorimetric Immunoassays with Boronic Acid-Decorated, Peroxidase-like Metal-Organic Frameworks as the Carriers of Antibodies and Enzymes.

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

CeOMikrochimica acta · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ting SunGuizhou Provincial University Key Laboratory of Advanced Functional Electronic Materials, School of Chemistry and Materials Science, Guizhou Education University, Guiyang 550018, China.

Xinyao YiCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.ORCID 0000-0002-9218-7161

Lin LiuCollege of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China.ORCID 0000-0001-7982-6005

Feng ZhaoGuizhou Provincial University Key Laboratory of Advanced Functional Electronic Materials, School of Chemistry and Materials Science, Guizhou Education University, Guiyang 550018, China.ORCID 0009-0008-0420-295X

Funding

the Guizhou Education University Doctor Program 2021BS028the Guizhou Provincial University Key Laboratory of Advanced Functional Electronic Materials QJJ[2023]021the Science and Technology Foundation of Guizhou Province QKHJC-ZK[2022]332

6 · The paper itself

Abstract

The sensitivity of immunoassays is generally limited by the low signal reporter/recognition element ratio. Nanomaterials serving as the carriers can enhance the loading number of signal reporters, thus improving the detection sensitivity. However, the general immobilization strategies, including direct physical adsorption and covalent coupling, may cause the random orientation and conformational change in proteins, partially or completely suppressing the enzymatic activity and the molecular recognition ability. In this work, we proposed a strategy to load recognition elements of antibodies and enzyme labels using boronic acid-modified metal-organic frameworks (MOFs) as the nanocarriers for signal amplification. The conjugation strategy was proposed based on the boronate ester interactions between the carbohydrate moieties in antibodies and enzymes and the boronic acid moieties on MOFs. Both enzymes and MOFs could catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) by H

Indexed as

Boronic AcidsColorimetryMetal-Organic FrameworksAntibodiesBenzidinesBiosensing TechniquesHorseradish PeroxidaseHumansHydrogen PeroxideImmunoassayOxidation-ReductionProstate-Specific Antigen3,3',5,5'-tetramethylbenzidineAntibodiesBenzidinesBoronic AcidsHorseradish PeroxidaseHydrogen PeroxideMetal-Organic FrameworksProstate-Specific Antigenboronic acidcolorimetric immunoassaymetal-organic frameworksignal amplification

Identifiers

PMID38998952

DOI10.3390/molecules29133000

PMCPMC11243670

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.