ReviewHealthcare (Basel, Switzerland)2024
Characteristics and Epidemiology of Megaprostheses Infections: A Systematic Review.
Review in Healthcare (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Successful implant salvage of a delayed tibial megaprosthesis infection using continuous local antibiotic perfusion: a case report.International journal of surgery case reports · 2026Article
- Salvage of Infected Dynamic Hip Screw and Distal Femur Nail Fixation for Ipsilateral Femoral Neck and Femoral Shaft Fracture Using Antibiotic-Coated Custom Long-Stem Austin Moore Prosthesis - A Rare Case Report.Journal of orthopaedic case reports · 2026Article
- Infection of a Total Femur Megaprosthesis: A Retrospective Study of Clinical and Functional Outcomes.Cureus · 2026Article
- Management of periprosthetic proximal femoral fracture of megaprosthesis with limited residual bone stock: A case report.International journal of surgery case reports · 2025Article
- Evaluation of Zimmer® segmental distal femur mega-prostheses: Patient survival, surgical outcomes and functional outcome.Journal of bone oncology · 2025Article
- Proximal femur replacement in oncologic lesion: hemiarthroplasty vs total hip arthroplasty-a multicentric retrospective study.Journal of orthopaedic surgery and research · 2025Article
- Knee-Sparing Resection and Reconstruction Surgery for Bone Sarcoma Using 3D-Surgical Approach: Average of 5-Year Follow-Up.Medicina (Kaunas, Lithuania) · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMegaprostheses were first employed in oncological orthopedic surgery, but more recently, additional applications have arisen. These implants are not without any risks and device failure is quite frequent. The most feared complication is undoubtedly the implants' infection; however, the exact incidence is still unknown. This systematic review aims to estimate in the current literature the overall incidence of megaprosthesis infections and to investigate possible risk/protective factors.
methodsWe conducted a systematic search for studies published from July 1971 to December 2023 using specific keywords. To be included, studies needed to report either the megaprosthesis anatomical site, and/or whether the megaprosthesis was coated, and/or the surgical indication as oncological or non-oncological reasons.
resultsThe initial literature search resulted in 1281 studies. We evaluated 10,456 patients and the overall infection rate was 12%. In cancer patients, the infection rate was 22%, while in non-oncological patients, this was 16% (trauma 12%, mechanical failure 17%, prosthetic joint infections 26%). The overall infection rates comparing coated and uncoated implants were 10% and 12.5%, respectively.
conclusionsThe number of megaprosthesis implants is increasing considerably. In traumatological patients, the infection rate is lower compared to all the other subgroups, while the infection rate remains higher in the cancer patient group. As these devices become more common, focused studies exploring epidemiological data, clinical outcomes, and long-term complications are needed to address the uncertainties in prevention and management.
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