Evidence map›Paper›PMID 38998509›Full record

ArticleFoods (Basel, Switzerland)2024

Bixin, a New Atheroprotective Carotenoid Candidate, Prevents oxLDL-Induced Cytotoxicity and Mitochondrial Dysfunction in Macrophages: Involvement of the Nrf2 and NF-κB Pathways.

Sabrina Somacal, Luana Caroline Schüler da Silva, Jade de Oliveira, Tatiana Emanuelli, Andreza Fabro de Bem

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sabrina SomacalGraduate Program on Pharmacology, Center of Health Sciences, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil.ORCID 0000-0002-8845-321X
Luana Caroline Schüler da SilvaDepartment of Biochemistry, Federal University of Santa Catarina, Florianopolis 88040-900, SC, Brazil.
Jade de OliveiraDepartment of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre 90035-000, RS, Brazil.
Tatiana EmanuelliDepartment of Food Technology and Science, Center of Rural Sciences, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil.ORCID 0000-0003-0168-3416
Andreza Fabro de BemLaboratory of Bioenergetic and Metabolism, Institute of Biological Science, University of Brasília, Brasília 70910-900, DF, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq 424809-2018-4Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq 552440/2011-6Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES 27/2010Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES grants11/2009INCT-NIM-CNPq - National Institute of Science and Technology on Neuromodulation 485489/2014-1
6 · The paper itself

Abstract

The accumulation of oxidized low-density lipoprotein (oxLDL) and its toxicity in the arterial wall have been implicated in atherosclerosis. This study aimed to investigate the mechanisms underlying the atheroprotective effect of bixin, a carotenoid obtained from the seeds of the tropical plant

Indexed as

Bixa orellanafoam cellsinflammationlycopeneoxidative stress

Identifiers

PMID38998509
PMCPMC11241531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.