Evidence map›Paper›PMID 38998041›Full record

ArticleAnimals : an open access journal from MDPI2024

Use of Microalgae-Derived Astaxanthin to Improve Cytoprotective Capacity in the Ileum of Heat-Induced Oxidative Stressed Broilers.

Donna Lee Kuehu, Yuanyuan Fu, Masaki Nasu, Hua Yang, Vedbar S Khadka, Youping Deng

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. DietaryFrontiers in veterinary science · 2025
    Article
  3. Review
  4. Effects of Heat-Induced Oxidative Stress and Astaxanthin on theCurrent issues in molecular biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Donna Lee KuehuBioinformatics Core, Department of Quantitative Health Sciences, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.ORCID 0000-0003-1367-8366
Yuanyuan FuBioinformatics Core, Department of Quantitative Health Sciences, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Masaki NasuBioinformatics Core, Department of Quantitative Health Sciences, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Hua YangBioinformatics Core, Department of Quantitative Health Sciences, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.ORCID 0000-0002-4573-3932
Vedbar S KhadkaBioinformatics Core, Department of Quantitative Health Sciences, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.ORCID 0000-0002-8652-2904
Youping DengBioinformatics Core, Department of Quantitative Health Sciences, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Benjamin C. Fogelgren · 2017 to 2026
$59.5M
Tracking and Evaluation CoreU54GM138062 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI OKAMOTO, SCOTT KIYOSHI · 2021 to 2025
$15.5M
Pacific Center for Genome ResearchU54HG013243 · NHGRI · UNIVERSITY OF HAWAII AT MANOA · PI Alexandra Margaret Lynn Binder, Youping Deng · 2023 to 2026
$10.8M
The Hawaii Advanced Training in Artificial Intelligence for Precision Nutrition Science Research (AIPrN)T32DK137523 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI Youping Deng, RACHEL NOVOTNY · 2023 to 2026
$1.7M
Live-Cell Imaging System with TIRF and PhotomanipulationS10OD028515 · OD · UNIVERSITY OF HAWAII AT MANOA · PI FARRAR, CHRISTINE · 2020 to 2020
$382k
NHGRI NIH HHS U54 HG013243NIDDK NIH HHS T32 DK137523NIGMS NIH HHS P20 GM103466NIGMS NIH HHS U54 GM138062NIH HHS S10 OD028515NIH HHS T32DK137523, U54GM138062, U54MD007601, P30GM114737, P20GM103466, P20GM139753, U54HG013243NIMHD NIH HHS U54 MD007601NSF 1745130
6 · The paper itself

Abstract

The gastrointestinal tract has a pivotal role in nutrient absorption, immune function, and overall homeostasis. The ileum segment of the small intestine plays respective roles in nutrient breakdown and absorption. The purpose of this study was to investigate the impact of heat-induced oxidative stress and the potential mitigating effects of an astaxanthin antioxidant treatment on the ileum of broilers. By comparing the growth performance and gene expression profiles among three groups-thermal neutral, heat stress, and heat stress with astaxanthin-thermal neutral temperature conditions of 21-22 °C and heat stress temperature of 32-35 °C, this research aims to elucidate the role of astaxanthin in supporting homeostasis and cellular protection in the ileum. Results showed both treatments under heat stress experienced reduced growth performance, while the group treated with astaxanthin showed a slightly lesser decline. Results further showed the astaxanthin treatment group significantly upregulated in the cytoprotective gene expression for

Indexed as

astaxanthinbroilerscytoprotective capacityheat stressileumoxidative stress

Identifiers

PMID38998041
PMCPMC11240551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.