Evidence map›Paper›PMID 38997759›Full record

Observational studyCritical care (London, England)2024

Resilience after severe critical illness: a prospective, multicentre, observational study (RESIREA).

Alice Mathieu, Jean Reignier, Amélie Le Gouge, Gaetan Plantefeve, Jean-Paul Mira, Laurent Argaud, Pierre Asfar, Julio Badie, Nicolae-Vlad Botoc, Hoang-Nam Bui and 37 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Nutritional Recovery After Critical Illness: A Qualitative Study of ICU Survivors' Experiences After Hospital Discharge.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Getting valuable and valid insight in life after ICU: evaluating the representativeness of a large cohort of ICU survivors.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Alice MathieuLaboratoire de Psychologie: Dynamiques Relationnelles Et Processus Identitaires (Psy-DREPI), Université de Bourgogne Franche-Comté, EA7458, Dijon, France.
Jean ReignierCHU Nantes, Movement - Interactions - Performance, MIP, UR 4334, Nantes Université, 44000, Nantes, France. jean.reignier@chu-nantes.fr.
Amélie Le GougeInserm CIC 1415, Tours, France.
Gaetan PlantefeveService de Médecine Intensive Réanimation, Centre Hospitalier d'Argenteuil, Argenteuil, France.
Jean-Paul MiraService de Médecine Intensive Réanimation, Hôpital Cochin, Groupe Hospitalier Paris Centre-Université Paris Cité, Assistance Publique -Hôpitaux de Paris, Paris, France.
Laurent ArgaudService de Médecine Intensive Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
Pierre AsfarService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Angers, Angers, France.
Julio BadieService de Médecine Intensive Réanimation, Hôpital Nord Franche Comté, Trevenans, France.
Nicolae-Vlad BotocService de Médecine Intensive Réanimation, Centre Hospitalier de Saint Malo, Saint-Malo, France.
Hoang-Nam BuiService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Delphine ChatellierService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.
Louis ChauvelotService de Médecine Intensive Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France.
Christophe CraccoService de Médecine Intensive Réanimation, Centre Hospitalier d'Angoulême, Angoulême, France.
Michael DarmonUniversité Paris Cité ; Assistance Publique -Hôpitaux de Paris, Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Saint Louis, Paris, France.
Agathe DelboveService de Réanimation Polyvalente, Centre Hospitalier Bretagne-Atlantique, Vannes, France.
Jérôme DevaquetService de Réanimation Polyvalente, Hôpital Foch, Suresnes, France.
Louis-Marie DumontService de Médecine Intensive Réanimation, Hôpital Louis-Mourier, Assistance Publique -Hôpitaux de Paris, Colombes, France.
Olivier GontierService de Médecine Intensive Réanimation, Centre Hospitalier de Chartres, Chartres, France.
Samuel GroyerService de Médecine Intensive Réanimation, Centre Hospitalier de Montauban, Montauban, France.
Yannick HourmantCHU Nantes, INSERM, Nantes Université, Anesthesie Reanimation, CIC 1413, Nantes, France.
Samir JaberService de Réanimation Chirurgicale, Hôpital Saint-Eloi, CHU de Montpellier, Montpellier, France.
Fabien LambiotteService de Médecine Intensive Réanimation, Centre Hospitalier de Valenciennes, Valenciennes, France.
Benjamin MadeuxService de Médecine Intensive Réanimation, Centre Hospitalier de Bigorre, Tarbes, France.
Julien MaizelService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France.
Olivier MartinetService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de la Réunion, Saint-Denis, La Réunion, France.
Virginie MaximeService de Médecine Intensive Réanimation, Hôpital Raymond Poincaré, Assistance Publique Hôpitaux de Paris, Garches, France.
Emmanuelle MercierService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Tours, CRICS-TRIGGERSEP Network Tours, Tours, France.
Mai-Anh NayService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire d'Orléans, Orléans, France.
Saad NseirMédecine Intensive-Réanimation, CHU Lille, 59000, Lille, France.
Gael PitonService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Besançon, Besançon, France.
Jean-Pierre QuenotService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire François Mitterrand, Dijon, France.
Anne RenaultService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire La Cavale Blanche, Brest, France.
Jean-Philippe RigaudService de Médecine Intensive Réanimation, Centre Hospitalier de Dieppe, Dieppe, France.
Francis SchneiderService de Médecine Intensive Réanimation, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Michel SirodotService de Médecine Intensive Réanimation, Centre Hospitalier Annecy Genevois, Epagny Metz-Tessy, France.
Bertrand SouweineService de Médecine Intensive Réanimation, Centre Hospitalier Universitaire Gabriel-Montpied, Clermont-Ferrand, France.
Fabienne TamionService de Médecine Intensive Réanimation, Hôpital Charles Nicolle, Centre Hospitalier Universitaire de Rouen; Normandie Université, UNIROUEN, Inserm U1096, FHU-REMOD-VHF, Rouen, France.
Didier ThéveninService de Médecine Intensive Réanimation, Centre Hospitalier de Lens, Lens, France.
Nathalie Thieulot-RolinService de Médecine Intensive Réanimation, Groupe Hospitalier Sud Ile de France, Melun, France.
Francois TinturierService de Réanimation Chirurgicale, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France.
Patrice TirotService de Médecine Intensive Réanimation, Centre Hospitalier du Mans, Le Mans, France.
Isabelle VinatierService de Médecine Intensive Réanimation, Centre Hospitalier Départemental de la Vendée, La Roche sur Yon, France.
Christophe VinsonneauService de Médecine Intensive Réanimation, Centre Hospitalier de Béthune, Béthune, France.
Jean-Baptiste LascarrouCHU Nantes, Movement - Interactions - Performance, MIP, UR 4334, Nantes Université, 44000, Nantes, France.
Alexandra LaurentLaboratoire de Psychologie: Dynamiques Relationnelles Et Processus Identitaires (Psy-DREPI), Université de Bourgogne Franche-Comté, EA7458, Dijon, France. alexandra.laurent@u-bourgogne.fr.
NUTRIREA-3 Trial Investigators
Clinical Research In Intensive Care and Sepsis (CRICS-TRIGGERSEP) Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCritical-illness survivors may experience post-traumatic stress disorder (PTSD) and quality-of-life impairments. Resilience may protect against psychological trauma but has not been adequately studied after critical illness. We assessed resilience and its associations with PTSD and quality of life, and also identified factors associated with greater resilience.

methodsThis prospective, multicentre, study in patients recruited at 41 French ICUs was done in parallel with the NUTRIREA-3 trial in patients given mechanical ventilation and vasoactive amines for shock. Three months to one year after intensive-care-unit admission, survivors completed the Connor-Davidson Resilience Scale (CD-RISC-25), Impact of Event-Revised scale for PTSD symptoms (IES-R), SF-36 quality-of-life scale, Multidimensional Scale of Perceived Social Support (MSPSS), and Brief Illness Perception Questionnaire (B-IPQ).

resultsOf the 382 included patients, 203 (53.1%) had normal or high resilience (CD-RISC-25 ≥ 68). Of these resilient patients, 26 (12.8%) had moderate to severe PTSD symptoms (IES-R ≥ 24) vs. 45 (25.4%) patients with low resilience (p = 0.002). Resilient patients had higher SF-36 scores. Factors independently associated with higher CD-RISC-25 scores were higher MSPSS score indicating stronger social support (OR, 1.027; 95%CI 1.008-1.047; p = 0.005) and lower B-IPQ scores indicating a more threatening perception of the illness (OR, 0.973; 95%CI 0.950-0.996; p = 0.02).

conclusionsResilient patients had a lower prevalence of PTSD symptoms and higher quality of life scores, compared to patients with low resilience. Higher scores for social support and illness perception were independently associated with greater resilience. Thus, our findings suggest that interventions to strengthen social support and improve illness perception may help to improve resilience. Such interventions should be evaluated in trials with PTSD mitigation and quality-of-life improvement as the target outcomes.

Indexed as

Critical IllnessQuality of LifeResilience, PsychologicalStress Disorders, Post-TraumaticAdultAgedFemaleFranceHumansIntensive Care UnitsMaleMiddle AgedProspective StudiesSocial SupportSurveys and QuestionnairesCritical illnessIllness perceptionPost-traumatic stress disorderQuality of lifeResilienceSocial support

Identifiers

PMID38997759
PMCPMC11245798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.