Evidence map›Paper›PMID 38997689›Full record

ArticleBMC public health2024

Temporal relationship between hepatic steatosis and fasting blood glucose elevation: a longitudinal analysis from China and UK.

Yujie Liu, Xian Liang, Yifan Hu, Ning Zhang, Xingren Zhu, Yuemei Feng, Zixiu Qin, Zihao Wang, Baima Kangzhuo, Xiong Xiao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yujie Liu *Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, CN, 610041, China.
Xian Liang *Chengdu Center for Disease Control and Prevention, Chengdu, China.
Yifan HuDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, CN, 610041, China.
Ning ZhangDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, CN, 610041, China.
Xingren ZhuDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, CN, 610041, China.
Yuemei FengSchool of Public Health, Kunming Medical University, Kunming, China.
Zixiu QinSchool of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.
Zihao WangChongqing Center for Disease Control and Prevention, Chongqing, China.
Baima KangzhuoHigh Altitude Health Science Research Center of Tibet University, Lhasa, Tibet, China.
Xiong XiaoDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, CN, 610041, China. xiaoxiong.scu@scu.edu.cn.
Xing ZhaoDepartment of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, CN, 610041, China.

Funding

National Natural Science Foundation of China 82273740Sichuan Province Science and Technology Support Program 2024NSFSC0552
6 · The paper itself

Abstract

backgroundThe link between nonalcoholic fatty liver disease and type 2 diabetes has not been fully established. We investigated the temporal relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D), quantitatively assessed the impact, and evaluated the related mediation effect.

methodsThis study involved participants from the China Multi-Ethnic Cohort Study and the UK Biobank. We performed cross-lagged path analysis to compare the relative magnitude of the effects between NAFLD and T2D using two-period biochemical data. Hepatic steatosis and fasting blood glucose elevation (FBG) represented NAFLD and T2D respectively. We fitted two separate Cox proportional-hazards models to evaluate the influence of hepatic steatosis on T2D. Furthermore, we applied the difference method to assess mediation effects.

resultsIn cross-lagged path analyses, the path coefficients from baseline hepatic steatosis to first repeat FBG (β

conclusionsOur findings contribute to determining the sequential relationship between NAFLD and T2D in the causal pathway, highlighting that the dominant pathway in the relationship between these two early stages of diseases was the one from hepatic steatosis to fasting blood glucose elevation. Individuals having NAFLD face a significantly increased risk of T2D and require long-term monitoring of their glucose status as well.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2FastingNon-alcoholic Fatty Liver DiseaseAdultAgedChinaFemaleHumansLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsRisk FactorsTime FactorsUnited KingdomBlood GlucoseHepatic steatosisNAFLDObesityType 2 diabetes

Identifiers

PMID38997689
PMCPMC11241918

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.