Evidence map›Paper›PMID 38997672›Full record

ArticleBMC pediatrics2024

The effect of cesarean delivery on the neonatal gut microbiome in an under-resourced population in the Bronx, NY, USA.

Sandra E Reznik, Ayodele J Akinyemi, David Harary, Mariam S Latuga, Mamta Fuloria, Maureen J Charron

Abstract read
In one paragraph

Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandra E ReznikDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
Ayodele J AkinyemiDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
David HararySidney Kimmel Medical College, Philadelphia, PA, USA.
Mariam S LatugaDepartment of Pediatrics, Division of Neonatology, The Children's Hospital at Montefiore Albert Einstein College of Medicine, 1601 Tenbroeck Avenue, 2nd floor, Bronx, NY, 10461, USA.
Mamta FuloriaDepartment of Pediatrics, Division of Neonatology, The Children's Hospital at Montefiore Albert Einstein College of Medicine, 1601 Tenbroeck Avenue, 2nd floor, Bronx, NY, 10461, USA. mfuloria@montefiore.org.
Maureen J CharronDepartment of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forch. 312, Bronx, NY, 10461, USA. maureen.charron@einsteinmed.edu.

Funding

Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth RestrictionR01HD092533 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHARRON, MAUREEN J, FULORIA, MAMTA · 2018 to 2022
$3.8M
Training in Intellectual and Developmental Disabilities (IDD) ResearchT32HD098067 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MOLHOLM, SOPHIE, WALKLEY, STEVEN UPSHAW · 2020 to 2024
$1.3M
National Institute of Child Health and Human Development HD092533-01A1NICHD NIH HHS R01 HD092533NICHD NIH HHS T32 HD098067
6 · The paper itself

Abstract

backgroundNeonatal and early-life gut microbiome changes are associated with altered cardiometabolic and immune development. In this study, we explored Cesarean delivery effects on the gut microbiome in our high-risk, under-resourced Bronx, NY population.

resultsFecal samples from the Bronx MomBa Health Study (Bronx MomBa Health Study) were categorized by delivery mode (vaginal/Cesarean) and analyzed via 16 S rRNA gene sequencing at four timepoints over the first two years of life. Bacteroidota organisms, which have been linked to decreased risk for obesity and type 2 diabetes, were relatively reduced by Cesarean delivery, while Firmicutes organisms were increased. Organisms belonging to the Enterococcus genus, which have been tied to aberrant immune cell development, were relatively increased in the Cesarean delivery microbiomes.

conclusionDue to their far-reaching impact on cardiometabolic and immune functions, Cesarean deliveries in high-risk patient populations should be carefully considered.

Indexed as

Cesarean SectionFecesGastrointestinal MicrobiomeBacillotaBacteroidetesEnterococcusFemaleHumansInfantInfant, NewbornMaleNew York CityPregnancyRNA, Ribosomal, 16SRNA, Ribosomal, 16SCesarean deliveryGut MicrobiomeNeonatal outcomesPregnancyUnder-resourced Population

Identifiers

PMID38997672
PMCPMC11245842

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.