ArticleNature medicine2024
Hippocampal network activity forecasts epileptic seizures.
Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed.
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Article
- Article
- Pathway to Adaptive Neuromodulation: Modeling Epileptogenic Brain States Using SEEG.Epilepsy currents · 2026Article
- At-home movement state classification using totally implantable cortical-basal ganglia neural interface.Science advances · 2026Article
- Electrographic cue-reactivity co-localizes with accumbens deep brain stimulation in a case of opioid use disorder.Nature communications · 2026Article
- Soft sonocapacitor with topologically integrated piezodielectric nanospheres enables wireless epidural closed-loop neuromodulation.Nature communications · 2026Article
- Dataset of chronic intracranial EEG of epilepsy patients via responsive neurostimulation system.Frontiers in neuroscience · 2026Article
- Collapse of interictal suppressive networks permits seizure spread.Brain : a journal of neurology · 2025Article
- Stronger pre-surgical functional connectivity networks are associated with improved surgical outcome in temporal lobe epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- High energy consumption characterizes abnormal brain state transitions in temporal lobe epilepsy.Neurobiology of disease · 2025Article
- Multiscale predictive modeling robustly improves the accuracy of pseudo-prospective seizure forecasting in drug-resistant epilepsy.bioRxiv : the preprint server for biology · 2025Article
- Massive Activation of GABABiomolecules · 2025Review
- Mechanistic insights into the interaction between epilepsy and sleep.Nature reviews. Neurology · 2025Review
- Can brain network analyses guide epilepsy surgery?Current opinion in neurology · 2025Review
- Intrinsic brain network stability during kainic acid-induced epileptogenesis.Epilepsia open · 2025Article
- Seizure prediction and forecasting: a scoping review.Current opinion in neurology · 2025Article
- Long-Term Ambulatory Intracranial EEG.Stereotactic and functional neurosurgery · 2025Review
- Editorial: Seizure forecasting tools, biomarkers and devices.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Seizures in people with epilepsy were long thought to occur at random, but recent methods for seizure forecasting enable estimation of the likelihood of seizure occurrence over short horizons. These methods rely on days-long cyclical patterns of brain electrical activity and other physiological variables that determine seizure likelihood and that require measurement through long-term, multimodal recordings. In this retrospective cohort study of 15 adults with bitemporal epilepsy who had a device that provides chronic intracranial recordings, functional connectivity of hippocampal networks fluctuated in multiday cycles with patterns that mirrored cycles of seizure likelihood. A functional connectivity biomarker of seizure likelihood derived from 90-s recordings of background hippocampal activity generalized across individuals and forecasted 24-h seizure likelihood as accurately as cycle-based models requiring months-long baseline recordings. Larger, prospective studies are needed to validate this approach, but our results have the potential to make reliable seizure forecasts accessible to more people with epilepsy.
Indexed as
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38997606What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.