ArticlePediatric surgery international2024
Impact of hepatocyte growth factor on the colonic morphology and gut microbiome in short bowel syndrome rat model.
Article in Pediatric surgery international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Jugular Venous Catheterization-Enhanced CT Angiography for In Vivo 3D Visualization of Cardiopulmonary Vasculature in Sprague-Dawley Rats.Pulmonary circulation · 2025Article
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Authors and funding
17 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to investigate the impact of hepatocyte growth factor (HGF) on colonic morphology and gut microbiota in a rat model of short bowel syndrome (SBS).
methodsSD rats underwent jugular vein catheterization for total parenteral nutrition (TPN) and 90% small bowel resection [TPN + SBS (control group) or TPN + SBS + intravenous HGF (0.3 mg/kg/day, HGF group)]. Rats were harvested on day 7. Colonic morphology, gut microflora, tight junction, and Toll-like receptor-4 (TLR4) were evaluated.
resultsNo significant differences were observed in the colonic morphological assessment. No significant differences were observed in the expression of tight junction-related genes in the proximal colon. However, the claudin-1 expression tended to increase and the claudin-3 expression tended to decrease in the distal colon of the HGF group. The Verrucomicrobiota in the gut microflora of the colon tended to increase in the HGF group. The abundance of most LPS-producing microbiota was lower in the HGF group than in the control group. The gene expression of TLR4 was significantly downregulated in the distal colon of the HGF group.
conclusionHGF may enhance the mucus barrier through the tight junctions or gut microbiome in the distal colon.
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