Evidence map›Paper›PMID 38997598›Full record

ArticleTranslational stroke research2025

What to Measure in Aneurysmal Subarachnoid Haemorrhage Research-An International Delphi Survey.

Christopher R Andersen, Justin Presseau, Bev Shea, Maria Luisa Marti, Madeline McCoy, Gordon Fernie, Lauralyn McIntyre, Anthony Delaney, Michaël Chassé, Victoria Saigle and 15 more

Abstract read
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Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Christopher R AndersenMalcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, Australia.
Justin PresseauMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Bev SheaMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Maria Luisa MartiMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Madeline McCoyMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Gordon FernieMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Lauralyn McIntyreMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Anthony DelaneyMalcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, Australia.
Michaël ChasséDepartment of Medicine, Division of Critical Care, Centre Hospitalier de L'Université de Montréal, Montréal, Québec, Canada.
Victoria SaigleMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Shawn MarshallMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Dean A FergussonMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ian GrahamMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Jamie BrehautMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Alexis F TurgeonDepartment of Anesthesiology and Critical Care, Division of Critical Care Medicine, Université Laval, Québec City, Québec, Canada.
François LauzierPopulation Health and Optimal Health Practice Research Unit (Trauma - Emergency - Critical Care Medicine) CHU de Québec-Université Laval Research Centre, Québec City, Québec, Canada.
Peter TugwellMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Xiaohui ZhaInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Phil TalbotCritical Care Program, The George Institute for Global Health, University of New South Wales Sydney, Sydney, Australia.
John MuscedereDepartment of Critical Care Medicine, Queen's University, Kingston, ON, Canada.
John C MarshallDepartments of Surgery and Critical Care Medicine, Unity Health Toronto, Toronto, ON, Canada.
Kednapa ThavornMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Donald GriesdaleDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Canadian Critical Care Trials Group
Shane W EnglishMethodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada. senglish@toh.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aneurysmal subarachnoid haemorrhage (aSAH) is a devastating condition with high mortality and morbidity. The outcome measures used in aSAH clinical research vary making it challenging to compare and combine different studies. Additionally, there may be a mismatch between the outcomes prioritized by patients, caregivers, and health care providers and those selected by researchers. We conducted an international, online, multiple round Delphi study to develop consensus on domains (where a domain is a health concept or aspect) prioritized by key stakeholders including those with lived experience of aSAH, health care providers, and researchers, funders, or industry professionals. One hundred seventy-five people participated in the survey, 59% of whom had lived experience of aSAH. Over three rounds, 32 domains reached the consensus threshold pre-defined as 70% of participants rating the domain as being critically important. During the fourth round, participants ranked the importance of each of these 32 domains. The top ten domains ranked highest to lowest were (1) Cognition and executive function, (2) Aneurysm obliteration, (3) Cerebral infarction, (4) Functional outcomes including ability to walk, (5) Delayed cerebral ischemia, (6) The overall quality of life as reported by the SAH survivor, (7) Changes to emotions or mood (including depression), (8) The basic activities of daily living, (9) Vasospasm, and (10) ICU complications. Our findings confirm that there is a mismatch between domains prioritized by stakeholders and outcomes used in clinical research. Our future work aims to address this mismatch through the development of a core outcome set in aSAH research.

Indexed as

Outcome Assessment, Health CareSubarachnoid HemorrhageAdultDelphi TechniqueFemaleHumansInternationalityMaleMiddle AgedQuality of LifeSurveys and QuestionnairesCerebral aneurysmCore outcome setPatient-important outcomesSubarachnoid hemorrhage

Identifiers

PMID38997598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.