Evidence map›Paper›PMID 38997335›Full record

ArticleScientific reports2024

Fair AI-powered orthopedic image segmentation: addressing bias and promoting equitable healthcare.

Ismaeel A Siddiqui, Nickolas Littlefield, Luke A Carlson, Matthew Gong, Avani Chhabra, Zoe Menezes, George M Mastorakos, Sakshi Mehul Thakar, Mehrnaz Abedian, Ines Lohse and 5 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Technology Review: The Hidden Influence of AI in Orthopaedic Surgery.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Artificial intelligence agents in orthopaedics: Concepts, capabilities and the road ahead.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ismaeel A Siddiqui *Department of Health Information Management, University of Pittsburgh, Pittsburgh, 15620, USA.
Nickolas Littlefield *Intelligent Systems Program, University of Pittsburgh, Pittsburgh, 5620, USA.
Luke A CarlsonDepartment of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, 15213, USA.
Matthew GongDepartment of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, 15213, USA.
Avani ChhabraDepartment of Health Information Management, University of Pittsburgh, Pittsburgh, 15620, USA.
Zoe MenezesDepartment of Health Information Management, University of Pittsburgh, Pittsburgh, 15620, USA.
George M MastorakosCortechs.ai, San Diego, 92122, USA.
Sakshi Mehul ThakarDepartment of Health Information Management, University of Pittsburgh, Pittsburgh, 15620, USA.
Mehrnaz AbedianDepartment of Health Information Management, University of Pittsburgh, Pittsburgh, 15620, USA.
Ines LohseDepartment of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, 15213, USA.
Kurt R WeissDepartment of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, 15213, USA.
Johannes F PlateDepartment of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, 15213, USA. platefj2@upmc.edu.
Hamidreza MoradiDepartment of Computer Science, North Carolina Agricultural and Technical State University, Greensboro, 27411, USA. hmoradi@ncat.edu.
Soheyla AmirianSeidenberg School of Computer Science and Information Systems, Pace University, New York, 10038, USA. samirian@pace.edu.
Ahmad P TaftiDepartment of Health Information Management, University of Pittsburgh, Pittsburgh, 15620, USA. tafti.ahmad@pitt.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AI-powered segmentation of hip and knee bony anatomy has revolutionized orthopedics, transforming pre-operative planning and post-operative assessment. Despite the remarkable advancements in AI algorithms for medical imaging, the potential for biases inherent within these models remains largely unexplored. This study tackles these concerns by thoroughly re-examining AI-driven segmentation for hip and knee bony anatomy. While advanced imaging modalities like CT and MRI offer comprehensive views, plain radiographs (X-rays) predominate the standard initial clinical assessment due to their widespread availability, low cost, and rapid acquisition. Hence, we focused on plain radiographs to ensure the utilization of our contribution in diverse healthcare settings, including those with limited access to advanced imaging technologies. This work provides insights into the underlying causes of biases in AI-based knee and hip image segmentation through an extensive evaluation, presenting targeted mitigation strategies to alleviate biases related to sex, race, and age, using an automatic segmentation that is fair, impartial, and safe in the context of AI. Our contribution can enhance inclusivity, ethical practices, equity, and an unbiased healthcare environment with advanced clinical outcomes, aiding decision-making and osteoarthritis research. Furthermore, we have made all the codes and datasets publicly and freely accessible to promote open scientific research.

Indexed as

Artificial IntelligenceAdultAgedAlgorithmsBiasFemaleHip JointHumansImage Processing, Computer-AssistedKneeKnee JointMagnetic Resonance ImagingMaleMiddle AgedOrthopedicsTomography, X-Ray Computed

Identifiers

PMID38997335
PMCPMC11245517

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.