ArticleScientific data2024
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center.
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In one paragraph
Article in Scientific data, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy.Nature communications · 2026Pooled it
- Study of blood linear RNA nominates CD55 and DLD as early-stage biomarkers for Parkinson's disease.Brain : a journal of neurology · 2026Article
- Blood-based circular RNAs for early diagnosis of Alzheimer's disease.Nature medicine · 2026Article
- Early detection of Alzheimer's disease with circular RNA from blood.Nature medicine · 2026Article
- A plasma-based protein signature combining NPTXR, ACHE, and p-tau217 predicts progression to symptomatic Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- ThebioRxiv : the preprint server for biology · 2026Article
- Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease.EBioMedicine · 2026Article
- Human IL-34 Deficiency Primes Microglia Toward Alzheimer's Disease-Associated States.medRxiv : the preprint server for health sciences · 2026Article
- A TAD-informed aging-brain xQTL atlas of multi-modal and cell-type-resolved regulatory variation.medRxiv : the preprint server for health sciences · 2026Article
- A Multi-Context Regulome-Wide Association Atlas for Genetic Studies of Aging Brain Disorders.medRxiv : the preprint server for health sciences · 2026Article
- LongAllele: a joint inference framework for allele-specific analysis on long-read bulk and single-cell RNA sequencing.bioRxiv : the preprint server for biology · 2026Article
- Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study.The Lancet. Neurology · 2026Article
- APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis.Nature genetics · 2026Article
- Analyses of plasma multi-omic data across ancestries identify novel pathways implicated in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Article
- CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex-specific alteration of multiple proteins involved in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neuroimaging-derived brain endophenotypes link molecular mechanisms to Alzheimer's disease and aging.medRxiv : the preprint server for health sciences · 2025Article
- A novel lncRNA FAM151B-DT regulates degradation of aggregation prone proteins.Molecular psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors.
Maria Victoria FernandezDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Menghan LiuDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Aleksandra BericDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9351-585X
Matt JohnsonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Arda CetinDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-4297-5984
Maulik PatelDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
John BuddeDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-7778-7276
Pat KohlfeldDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0004-9206-8244
Kristy BergmannDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Joseph LoweryDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Allison FlynnDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
William BrockDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Brenda Sanchez MontejoDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Jen GentschDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Nicholas SykoraDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Joanne NortonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Jen GentschDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Olga ValdezDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Priyanka GorijalaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Jessie SanfordDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Yichen SunDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Ciyang WangDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Dan WesternDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-3725-9553
Jigyasha TimsinaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Tassia Mangetti GoncalvesDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Anh N DoDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Yun Ju SungDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Guoyan ZhaoDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-5615-6774
John C MorrisDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Krista MoulderDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
David M HoltzmanDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID 0000-0002-3400-0856
Randall J BatemanDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID 0000-0002-7729-1702
Celeste KarchDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6854-5547
Jason HassenstabDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Chengjie XiongDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Suzanne E SchindlerDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID 0000-0002-1680-1465
Joyce Joy Balls-BerryDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Tammie L S BenzingerDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Richard J PerrinPathology and Immunology Department, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID 0000-0002-3443-7716
Andrea DennyDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
B Joy SniderDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Susan L StarkKnight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Laura IbanezDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. ibanezl@wustl.edu.
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. cruchagac@wustl.edu.ORCID 0000-0002-0276-2899
Funding
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5MImaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5MResearch Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7MUSING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITSRF1AG053303 · NIA · WASHINGTON UNIVERSITY · PI CLIMER, SHARLEE, CRUCHAGA, CARLOS · 2016 to 2020
$4.0MDissect the mechanisms of selective regional vulnerability in Lewy Body Dementias via comparative snRNA-seq analysisR01NS123571 · NINDS · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2021 to 2025
$3.6MGENETIC MODIFIERS OF CEREBROSPINAL FLUID TREM2 IN ALZHEIMER'S DISEASERF1AG058501 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS, PICCIO, LAURA · 2018 to 2018
$3.5MThe Familial Alzheimer Sequencing (FASe) ProjectU01AG058922 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS, GOATE, ALISON M · 2018 to 2022
$3.5MSex-specific Molecular Profiling to Understand Pathology and Identify Causal Genes and Drug Targets for Alzheimer's DiseaseRF1AG074007 · NIA · WASHINGTON UNIVERSITY · PI SUNG, YUNJU · 2021 to 2021
$2.7MIDENTIFYING RARE VARIANTS THAT INCREASE RISK FOR ALZHEIMER'S DISEASER01AG044546 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS · 2013 to 2017
$2.7MSex-specific Molecular Profiling to Understand Pathology and Identify Causal Genes and Drug Targets forAlzheimer's DiseaseR01AG074007 · NIA · WASHINGTON UNIVERSITY · PI YunJu Sung · 2024 to 2026
$2.4MPlasma Cell-Free RNA as Non-invasive Biomarker for NeurodegenerationR00AG062723 · NIA · WASHINGTON UNIVERSITY · PI IBANEZ, LAURA · 2022 to 2024
$729kNIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS R00 AG062723NIA NIH HHS R01 AG044546NIA NIH HHS R01 AG074007NIA NIH HHS R21 AG077643NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG058501NIA NIH HHS RF1 AG074007NIA NIH HHS U01 AG058922NIA NIH HHS U19 AG032438NINDS NIH HHS R01 NS123571U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review) P30AG066444
Abstract
The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer Disease. Over more than 40 years, research volunteers have been recruited to participate in cognitive, neuropsychologic, imaging, fluid biomarkers, genomic and multi-omic studies. Tissue and longitudinal data collected to foster, facilitate, and support research on dementia and aging. The Genetics and high throughput -omics core (GHTO) have collected of more than 26,000 biological samples from 6,625 Knight-ADRC participants. Samples available include longitudinal DNA, RNA, non-fasted plasma, cerebrospinal fluid pellets, and peripheral blood mononuclear cells. The GHTO has performed deep molecular profiling (genomic, transcriptomic, epigenomic, proteomic, and metabolomic) from large number of brain (n = 2,117), CSF (n = 2,012) and blood/plasma (n = 8,265) samples with the goal of identifying novel risk and protective variants, identify novel molecular biomarkers and causal and druggable targets. Overall, the resources available at GHTO support the increase of our understanding of Alzheimer Disease.
Indexed as
Alzheimer DiseaseBiomarkersDementiaGenomicsHumansMultiomicsProteomicsBiomarkers
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