Evidence map›Paper›PMID 38997303›Full record

ArticleScientific reports2024

Alcohol consumption during pregnancy differentially affects the fecal microbiota of dams and offspring.

Tamara S Bodnar, Garrett Ainsworth-Cruickshank, Vincent Billy, Laura Wegener Parfrey, Joanne Weinberg, Charlis Raineki

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Role of gut microbiota and its functional products in prenatal alcohol-induced anxiety-like behavior.Progress in neuro-psychopharmacology & biological psychiatry · 2025
    Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tamara S BodnarDepartment of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada. tamara.bodnar@ucalgary.ca.
Garrett Ainsworth-CruickshankDepartment of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Vincent BillyDepartment of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Laura Wegener ParfreyDepartment of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC, Canada.
Joanne WeinbergDepartment of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
Charlis RainekiDepartment of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

Funding

Prenatal Alcohol and NeuroimmunityR01AA022460 · NIAAA · UNIVERSITY OF BRITISH COLUMBIA · PI BODNAR, TAMARA SONIA, RAINEKI, CHARLIS · 2013 to 2024
$2.3M
Natural Sciences and Engineering Research Council of Canada USRANIAAA NIH HHS R01 AA022460
6 · The paper itself

Abstract

Microbiota imbalances are linked to inflammation and disease, as well as neurodevelopmental conditions where they may contribute to behavioral, physiological, and central nervous system dysfunction. By contrast, the role of the microbiota in Fetal Alcohol Spectrum Disorder (FASD), the group of neurodevelopmental conditions that can occur following prenatal alcohol exposure (PAE), has not received similar attention. Here we utilized a rodent model of alcohol consumption during pregnancy to characterize the impact of alcohol on the microbiota of dam-offspring dyads. Overall, bacterial diversity decreased in alcohol-consuming dams and community composition differed from that of controls in alcohol-consuming dams and their offspring. Bacterial taxa and predicted biochemical pathway composition were also altered with alcohol consumption/exposure; however, there was minimal overlap between the changes in dams and offspring. These findings illuminate the potential importance of the microbiota in the pathophysiology of FASD and support investigation into novel microbiota-based interventions.

Indexed as

Alcohol DrinkingFecesPrenatal Exposure Delayed EffectsAnimalsBacteriaDisease Models, AnimalEthanolFemaleFetal Alcohol Spectrum DisordersGastrointestinal MicrobiomeMaleMicrobiotaPregnancyRatsEthanol

Identifiers

PMID38997303
PMCPMC11245617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.