ReviewTranslational psychiatry2024
Trauma, adversity, and biological aging: behavioral mechanisms relevant to treatment and theory.
Review in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Post-traumatic stress disorder moderates the association between BrainAge acceleration and GrimAge acceleration.Neurobiology of aging · 2026Pooled it
- Lifetime non-relational traumatic experiences are associated with biological ageing.GeroScience · 2026Article
- Dimensions of early life adversity and accelerated biological aging in adolescents: an examination of fear-related mechanisms.Journal of behavioral medicine · 2026Article
- "We feel like we don't matter": the work experience of caring for long-term care residents with suspected trauma-related responsive behaviors.BMC health services research · 2026Article
- The moderating role of psychological resilience on brain aging and PTSD in a community sample of South African women.Neuroscience · 2026Article
- Interpersonal adversity and health across the life course.Current opinion in psychology · 2026Review
- Trauma exposure, PTSD, and methylation of the blood brain barrier claudin-5 gene.Psychoneuroendocrinology · 2026Article
- The role of health behaviors in links between stress and epigenetic aging.Brain, behavior, & immunity - health · 2026Article
- Epigenetic Clocks, Resilience, and Multi-Omics Ageing: A Review and the EpiAge-R Conceptual Framework.International journal of molecular sciences · 2026Review
- Article
- Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Early Life Stress Effects on Children's Biology, Behavior, and Health: Evidence, Mediators, Moderators, and Solutions.Annual review of psychology · 2026Review
- PTSD and suPAR: A multicohort investigation of chronic inflammation.Brain, behavior, and immunity · 2026Article
- Relationship stress and epigenetic age acceleration among older U.S. adults in the Midlife in the United States study.Epigenomics · 2025Article
- Trauma Exposure, PTSD, and Methylation of the Blood Brain Barrier Claudin-5 Gene.medRxiv : the preprint server for health sciences · 2025Article
- Epigenetic aging acceleration among World Trade Center-exposed community members.Scientific reports · 2025Article
- Examining the timing of trauma, PTSD onset, and DNA methylation: A multicohort investigation of candidate CpG sites.Journal of psychiatric research · 2025Article
- Early life stress, psychiatric conditions, and mitochondrial DNA copy number (mtDNAcn) in medically healthy young adults.Psychoneuroendocrinology · 2025Article
- Association of Psychological Resilience With Decelerated Brain Aging in Cognitively Healthy World Trade Center Responders.Biological psychiatry global open science · 2025Article
- Psychosocial Interventions Impact on Cardiometabolic, Neurobiological, Behavioral, and Immune Outcomes in People With a Serious Mental Illness: A Systematic Review.Health science reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Although stress and adversity are largely universal experiences, people exposed to greater hardship are at increased risk for negative health consequences. Recent studies identify accelerated biological aging as a mechanism that could explain how trauma and adversity gives rise to poor health, and advances in this area of study coincide with technological innovations in the measurement of biological aging, particularly epigenetic profiles consistent with accelerated aging derived from DNA methylation. In this review, we provide an overview of the current literature examining how adversity might accelerate biological aging, with a specific focus on social and health behaviors. The most extensive evidence in this area suggests that health-compromising behaviors, particularly smoking, may partially explain the association between adversity and accelerated aging. Although there is relatively less published support for the role of social behaviors, emerging evidence points to the importance of social connection as a mechanism for future study. Our review highlights the need to determine the extent to which the associations from adversity to accelerated aging are consistent with causal processes. As we consider these questions, the review emphasizes methodological approaches from the causal inference literature that can help deepen our understanding of how stress and trauma might result in poor health. The use of these methodologies will help provide evidence as to which behavioral interventions might slow aging and improve health, particularly among populations that more often experience adversity and trauma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.