Evidence map›Paper›PMID 38997217›Full record

ArticlePhysiological reports2024

The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity.

Gary S Goldfield, Jameason D Cameron, Ronald J Sigal, Glen P Kenny, Denis Prud'homme, Mathew Ngu, Angela S Alberga, Steve Doucette, Diana B Goldfield, Heather Tulloch and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gary S GoldfieldHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.ORCID 0000-0001-6216-7824
Jameason D CameronDepartment of Pharmacy, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Ronald J SigalSchool of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Glen P KennySchool of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Denis Prud'hommeSchool of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Mathew NguSchool of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Angela S AlbergaDepartment of Exercise Science, Concordia University, Montreal, Quebec, Canada.
Steve DoucetteDepartment of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.
Diana B GoldfieldLife Sciences, Queen's University, Kingston, Ontario, Canada.
Heather TullochDivision of Cardiac Prevention and Rehabilitation, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Helen ThaiHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Kevin R SimasHealthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.ORCID 0000-0002-2170-5371
Jeremy WalshDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada.

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (IRSC) MCT-71979
6 · The paper itself

Abstract

The brain derived-neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF, and is associated with obesity and some psychiatric disorders, but its relationship to health-related quality of life (HRQoL) remains unknown. This study examined, in youth with obesity, whether carriers of the BDNF Val66met polymorphism Met-alleles (A/A or G/A) differed from noncarriers (G/G) on HRQoL. The participants were 187 adolescents with obesity. Ninety-nine youth were carriers of the homozygous Val/Val (G/G) alleles, and 88 were carriers of the Val/Met (G/A) or Met/Met (A/A) alleles. Blood samples were drawn in the morning after an overnight fast for genotyping. HRQoL was measured using the Pediatric-Quality of Life core version. Compared to carriers of the Val66Met Val (G/G) alleles, carriers of the Met-Alleles reported significantly higher physical -HRQoL (p = 0.02), school-related HRQoL, (p = 0.05), social-related HRQoL (p = 0.05), and total HRQoL (p = 0.03), and a trend for Psychosocial-HRQoL. Research is needed to confirm our findings and determine whether carriers of the BDNF Val66Met homozygous Val (G/G) alleles may be at risk of diminished HRQoL, information that can influence interventions in a high-risk population of inactive youth with obesity.

Indexed as

Brain-Derived Neurotrophic FactorPediatric ObesityPolymorphism, Single NucleotideQuality of LifeAdolescentAllelesHomozygoteHumansMaleBrain-Derived Neurotrophic Factorbrain derived‐neurotrophic factor (BDNF)health‐related quality of life (HRQoL)obesitypolymorphismyouth

Identifiers

PMID38997217
PMCPMC11245332

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.