ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024
An In Vivo High-Resolution Human Brain Atlas of Synaptic Density.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Building an open infrastructure for molecular neuroimaging: Standards and tools from the OpenNeuroPET initiative.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Analysis of acute stroke-like lesions in MELAS: Distribution, potential boundaries and spreading pattern.Neuroimage. Reports · 2026Article
- Psilocybin's effect on human brain synaptic plasticity.Translational psychiatry · 2026Article
- Synaptic correlates of benzodiazepine tolerance.Molecular psychiatry · 2026Review
- Metabolism-weighted brain connectome reveals synaptic integration and vulnerability to neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Building an open ecosystem for molecular neuroimaging: standards and tools from the OpenNeuroPET initiative.bioRxiv : the preprint server for biology · 2026Article
- Discordance Between Spatial and Population Correlations From Human Brain Imaging Data.Human brain mapping · 2025Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer's disease: associations with Aβ, tau, synaptic proteins and APOE ε4.Translational neurodegeneration · 2025Article
- Synaptic Density in Multiple Sclerosis: An In Vivo Study Using [Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Increased Expression of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Brain of Chronic Diabetic Rats.Synapse (New York, N.Y.) · 2025Article
- Glucose metabolism echoes long-range temporal correlations in the human brain.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synapses are fundamental to the function of the central nervous system and are implicated in a number of brain disorders. Despite their pivotal role, a comprehensive imaging resource detailing the distribution of synapses in the human brain has been lacking until now. Here, we employ high-resolution PET neuroimaging in healthy humans (17F/16M) to create a 3D atlas of the synaptic marker Synaptic Vesicle glycoprotein 2A (SV2A). Calibration to absolute density values (pmol/ml) was achieved by leveraging postmortem human brain autoradiography data. The atlas unveils distinctive cortical and subcortical gradients of synapse density that reflect functional topography and hierarchical order from core sensory to higher-order integrative areas-a distribution that diverges from SV2A mRNA patterns. Furthermore, we found a positive association between IQ and SV2A density in several higher-order cortical areas. This new resource will help advance our understanding of brain physiology and the pathogenesis of brain disorders, serving as a pivotal tool for future neuroscience research.
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