Evidence map›Paper›PMID 38997156›Full record

ArticleGenes & development2024

Tert-expressing cells contribute to salivary gland homeostasis and tissue regeneration after radiation therapy.

Li Guan, Vignesh Viswanathan, Yuyan Jiang, Sivakamasundari Vijayakumar, Hongbin Cao, Junfei Zhao, Deana Rae Crystal Colburg, Patrick Neuhöfer, Yiru Zhang, Jinglong Wang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. circHERC1-A telomerase activator.Science advances · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Li GuanDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.
Vignesh ViswanathanDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.
Yuyan JiangDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.
Sivakamasundari VijayakumarInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
Hongbin CaoDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.
Junfei ZhaoDepartment of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA.
Deana Rae Crystal ColburgDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.
Patrick NeuhöferStanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA.
Yiru ZhangDepartment of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Jinglong WangDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.
Yu XuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.
Eyiwunmi E LaseindeDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.
Rachel HildebrandDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.
Mobeen RahmanDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.
Richard FrockDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.ORCID 0000-0001-6963-4931
Christina KongDepartment of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.
Philip A BeachyInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
Steven ArtandiStanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA.
Quynh-Thu LeDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA; qle@stanford.edu.ORCID 0000-0002-3682-1439

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Translational Biology CoreP01CA257907 · NCI · STANFORD UNIVERSITY · PI Maximilian Diehn, Quynh-Thu Xuan Le · 2022 to 2026
$12.0M
REVERSING CELLULAR IMMORTALITY IN CANCERR35CA197563 · NCI · STANFORD UNIVERSITY · PI ARTANDI, STEVEN E · 2015 to 2021
$6.4M
Precision imaging for risk stratification and personalized therapy of oropharyngeal cancerR01DE030894 · NIDCR · STANFORD UNIVERSITY · PI Quynh-Thu Xuan Le, Ruijiang Li · 2022 to 2026
$3.0M
The role of Galectin-1 in shaping the immune suppressive landscape in head and neck cancerR01DE029672 · NIDCR · STANFORD UNIVERSITY · PI LE, QUYNH-THU XUAN · 2021 to 2025
$2.9M
Salivary gland response to Desert hedgehog signaling as an antidote to damage from therapeutic radiationR01DE031724 · NIDCR · STANFORD UNIVERSITY · PI PHILIP A BEACHY · 2022 to 2026
$2.5M
NCI NIH HHS P01 CA257907NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA124435NCI NIH HHS R35 CA197563NIDCR NIH HHS R01 DE029672NIDCR NIH HHS R01 DE030894NIDCR NIH HHS R01 DE031724
6 · The paper itself

Abstract

Salivary gland homeostasis and regeneration after radiotherapy depend significantly on progenitor cells. However, the lineage of submandibular gland (SMG) progenitor cells remains less defined compared with other normal organs. Here, using a mouse strain expressing regulated CreERT2 recombinase from the endogenous Tert locus, we identify a distinct telomerase-expressing (Tert

Indexed as

HomeostasisRegenerationTelomeraseAnimalsCell ProliferationCells, CulturedCell SurvivalHumansMiceRadiotherapyReactive Oxygen SpeciesSalivary GlandsStem CellsSubmandibular GlandReactive Oxygen SpeciesTelomeraseTert protein, mouseprogenitor cellradiation therapysubmandibular glandtelomerasetissue regeneration

Identifiers

PMID38997156
PMCPMC11293384

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.